: For the treatment of hypertension & treatment of renal disease in patients withhypertension and type II diabetes mellitus, as part of an antihypertensive drugregimen.
Mechanism of Action
Inhibits the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively blocking binding of angiotensin Ii to receptor sites in many tissues.Therapeutic Effect: Lowers blood pressure.
: 150 mg daily. May be increased to 300 mg or combined with other antihypertensiveagents if patient is not sufficiently controlled. In hemodialyzed patients &elderly>75 yr 75 mg daily
: Intravascular volume depletion, renovascular hypertension, renalimpairment, kidney transplantation, hyperkalemia, aortic & mitral valve stenosis,obstructive hypertrophic, cardiomyopathy, ischemic cardiopathy, ischemicCV disease, primary aldosteronism & patients whose vascular tone & renal functiondepend predominantly on the activity of the rennin-angiotensin-aldosterone system.
Pregnancy Risk Category
C (D in 2