45 kg: 50 mg/kg to a maximum of 1 g of probenecid as a single dose. Don’tgive probenecid to children younger than age 2.Endocarditis prophylaxisfor dental, GI and GU procedures: Adults: 2 g P.O. 1 hour before procedure Post exposure prophylaxis to penicillin- susceptible anthrax: Adultsand Children older than age 9: 500 mg P.O t.i.d. for 60 days. Childrenyounger than age 9: 80 mg/kg daily P.O., divided t.i.d for 60 days
: Renal impairment, Severe hepatic dysfunction.
Pregnancy Risk Category
: CNS: lethargy, hallucinations, seizures, anxiety, confusionagitation, depression, dizziness, fatigue.GI: nausea, vomiting, diarrhea ,glossitis, stomatitis, gastritis, enterocolitis, abdominal pain, pseudomembranouscolitis, black hairy tongue GU: interstitial nephritis, nephropathy, vaginitisHematologic: anemia, thrombocytopenia, thrombocytopenic purpura,eosinophilia, leukopenia, hemolytic anemia, agranulocytosis. Other:hypersensitivity reactions, anaphylaxis, overgrowth of non susceptibleorganisms.
Contraindicated in patients hypersensitive to drug or other penicillins.