Brand Name: CalpolGeneric Name:
Paracetamol
Indications:
mild pain, fever
Drug Classification:
Antipyretics, non-opioid analgesics
Mechanism of Action:
Inhibits the synthesis of Prostaglandins that may serve asmediators of pain and fever, primarily in the CNS by inhibiting thecyclooxygenase(COX)enzyme.
Prostaglandins participate in the inflammatoryresponse, but
paracetamol has no appreciable anti-inflammatory action.
Dosage:
Adult: 325-650 mg q 4-6 hr or 1 g 3-4 times daily or 1300 mg q 8 hrs.Children (>14 yr): 650 mg q 4 hr prn.Children (12-14 yr): 640 mg q 4 hr.Children (11 yr): 480 mg q 4 hr prn.
Special Precautions:
Hepatic dse/Renal dse (lower chronic doses recommended),Chronic alcohol use/abuse, malnutrition.
Pregnancy Risk Category:
B
Adverse Reactions:
GI: Hepatic Failure, Hepatotoxicity(overdose)
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