Brand Name: ClexaneGeneric Name:
Prevent pulmonary embolism and deep
vein thrombosis after hip or kneereplacement surgery, abdominal surgery, patients with acute illness who are atincreased risk because of decreased mobility. To prevent ischemiccomplications of unstable angina and non-Q-wave MI with oral aspirintheraphy.
Mechanism of Action:
A low moleculer weight heparin derivative that acceleratesformation of anti-thrombin III-thrombin complex and deactivates thrombin, preventing conversion of fibrinogen to fibrin. Has higher anti-factor Xa toantifactor IIa activity ratio.
Initially at 40mg SC
q8 for 10 days.
History of Heparin induced thrombocytopenia with or withoutthrombosis. Do not administer by IM route. Renal or hepatic insufficiency,History of hepatic ulcer, arterial hypertension, diabetic retinophaty, shortly after neuro or ophth surgery.
Pregnancy Risk: B