Brand Name: Coversyl Generic Name: Perindopril Indication: Essential Hypertension, CHF.

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Brand Name: CoversylGeneric Name:

Perindopril

Indication

: Essential Hypertension, CHF. Prevention of Stroke recurrence in combination withIndapamide in patients with a history of cerebrovascular disease.

Drug Classification

: Antihypertensive (ACE Inhibitor)

Mechanism of Action

: A prodrug that is converted by the liver to the active metabolite perindroprilat, which inhibits ACE activity, thereby preventing conversion of angiotensinI to angiotensin II, a potent vasoconstrictor. Inhibition of ACE results in decreasedvasoconstriction and decreased aldosterone activity,thus reducing sodium water 4, 4 mgP.O. once daily. Increase dosage until blood pressure is controlled or to maximum of 1mg/day; usually maintenance dose is 4 to 8 mg oce daily; may be given it two divideddoses. Elderly patients:Initially, 4 mg P.O. daily as one dose or in two divided doses.Dosage may be increased by more than 8 mg/day only under close medicalsupervision.

Special Precaution:

Renal failure; renovascular hypertension; surgery/anesth; elderly.Hemodialysis: avoid combination with highly permeable membranes (polyacrylonitrile)

Pregnancy Risk Category

: C (D in second and third trimesters)

Adverse Reaction:

CNS: dizziness, asthenia, sleep disorder, paresthesia, depression, somnolence,nervousness, headache.CV: palpitations, edema, chest pain, abnormal ECG. EENT:rhinitis, sinusitis, ear infection, pharyngitis, tinnitus. GI: dyspepsia, diarrhea, abdominal

pain, nausea, vomiting, flatulence. GU: proteinuria, urinarytract infection, malesexual dysfunction, menstrual disorder. Musculoskeletal: back pain, hyperonia, neck pain, joint pain, myalgia, arthritis, arm or leg pain Respiratory: cough, upper respiratoryinfection SKIN: Rash OTHER: viral infection, injury, seasonal allergy

Contraindications

: Contraindicated in patients hypersensitive to drug or other ACE inhibitorsand in those with a history of angioedema secondary to ACE inhibitors. Alsocontraindicated in pregnant women.

Form

: Tablets 2mg, 4mg, 8 mg

Nursing Responsibility:

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Use cautiously in patients with a history of angioedema unrelated to ACE inhibitor therapy. Also use cautiously in patients with impaired renal function, heart failure,ischemic heart disease or renal artery stenosis, and in patients with collagen vascular disease, such as systemic lupus erythematosus or scleroderma.

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Therapy with thiazide diuretic produces a more favorable response. ACE inhibitorsappear to increase risk of angioedema in black patients.

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Angioedema involving the face extremities, lips, tongue, glottis, and larynx mayoccur. Stop drug and observe patient swelling disappear. If swelling is confined tolips and face, it will probably resolve without treatment, but antihistamines may beuseful in relieving symptoms.

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