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Brand name:
 
DiflucanGeneric name:
Fluconazole
Drug Classification:
Antibiotics (Antifungal)
Indication:
Adult: Oral or vaginal candidiasis unresponsive to nystatin or clotrimazole; nonlife-threatening
Candida
infections (cystitis, esophaglitis); treatment of hepatosplenic candidiasisand other 
Candida
infections in person unable to tolerate amphotericin B; treatment of cryptococcal infections; secondary prophylaxis in allogeneic bone marrow transplantrecipients.
Mechanism of action:
Interferes with cytochrome P-450 activity, decreasing ergosterol synthesis(principal sterol in fungal cell membrane) and inhibiting cell membrane formation.
Dose:
Adult Candidiasis, disseminated candidiasis & other invasive candidal infection 400 mg on the 1
st
day followed by 200 mg daily. Vaginal candidiasis150 mg as single oral dose. Oropharyngeal-candidiasis 50 mg once daily for 7-14 days. If necessary, continue treatment for longer periodsin patients w/ severely compromised immune function. Candidal infection of mucosa 50 mgdaily for 14- 30 days, may be increased up to 100 mg daily. Children mucosal candidiasis 3mg/kg. Systemic candidiasis 6-12 mg/kg daily. Prevention of candidiasis based on risk odeveloping fungal infections 50-400 mg once daily. Deep endemic mycoses200-400 mg dailyfor up to 2 yr. Cryptococcal meningitis & cryptococcal infections at other sites 400 mg on the1
st
day followed by 200- 400 once daily for atleast 6-8 wk. Prevention of relapse of cryptococcal meningitis in patients w/ AIDS 200 mg daily after a full course of primarytherapy. Atrophic oral candidiasis associated with dentures 50 mg once daily for 14 daysconcurrently w/ local antiseptic measures to the denture. Dermal infection including tinea
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