Brand Name: Diovan Generic Name: Valsartan Indications: Treatment of Hypertension,

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Brand name:

DiovanGeneric name:

Valsartan

Indications:

treatment of hypertension, heart failure.

Drug classification:

cardiovascular agent; angiotensin II-receptor (type AT

1

) antagonist;antihypertensive

Mechanism of action:

an angiotensin II-receptor (type AT

1

) antagonist; blocks the binding of angiotensin II to the AT

1

receptors found in many tissues.Angiotensin II is a potent vasoconstrictor and primary vasoactive hormone of the renin-angiotensin-aldosterone system.

Dosage: hypertension

Adult: PO 80mg qd (max: 320mg qd)

Heart failure

Adult: PO start with 40mg bid and titrate up to 160mg bid

Special precaution:

severe renal or hepatic impairment. Safety and efficacy in children<8 y are not established.

Pregnancy risk category:

C (1

st

trimester); D (2

nd

and 3

rd

trimester)

Adverse reaction:

Body as a whole: arthralgia. CNS: headache, dizziness. GI: diarrhea,nausea. Respiratory: cough, sinusitis. Metabolic: hyperkalemia

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