OBESITAS DAN INFLAMASI

OBESITAS DAN INFLAMASI

SITOKIN TNF IL-6 IL-1R SIFAT PROINFLAMASI PROINFLAMASI ANTIINFLAMASI

IL-10 MIF M-CSF TNFR LARUT C-REACTIVE PROTEIN HAPTOGLOBIN

ANTIINFLAMASI INHIBISI MIGRASI INHIBISI DIFERENSIASI MONOSIT/MAKROFAGA PROINFLAMASI PROINFLAMASI PROINFLAMASI

O2 DAN INFEKSI

O2 DAN NORMOXIA

PADA KEADAAN OKSIGEN BANYAK: HIF1 TIDAK STABIL KARENA DIDEGRADASI OLEH PROTEASOME Nizet and Johnson, 2009

Nizet and Johnson, 2009

O2 DAN HYPOXIA

REGULASI HIF PADA FUNGSI RESPONS IMUN BAWAAN FAGOSIT

Nizet and Johnson, 2009

Neutrophil function and O2 level

IN WOUND: < 30 mm Hg (< 1%) HEALTHY TISSUE: 20-70 mm Hg (2,5 9%)

BACTERICIDAL ACTIVITY OF NEUTROPHIS: OXIDATIVE KILLING, PRODUCTION OF O2FROM O2 (NEEDS 0->300 mm Hg O2)

Prolonged hypoxia
Increased levels of:
IL-1 (proinflammatory cytokines) IL-8 ( VEGF Angiopoeitin CXCR4 TNF (proinflammatory cytokines) IL-12
Nizet and Johnson, 2009)

Hypothermia and infection

Hypothermia and immune respone

Vasoconstriction in skin and subcutaneous vessels:
O2 delivery O2 tension in wound superoxide formation non specific neutrophil oxidative killing neutrophil killing ability T-cell mediated antibody production

monocyte HLA-DR surface expression Delayed clearance of TNF ( TNF host tissue injury and multiorgan dysfunction) IL-10 release (inflammatory cytokine)