DAFTAR ISI

DAFTAR
ISIi
BAB

PENDAHULUAN...1
BAB

II

PEMBAHASAN3
A. Clinical

Proteomics

&

Fetal

Diagnosis..3
B. Conventional

Biochemical

Markers......4
I.

Chromosomal

Aneuploidy

&

Protein

Markers......4
II.

Human

Fetoprotein...........4
III.

Inhibins

as

Diagnostic

Markers

in

Human

Reproduction............4
IV.

Triple

Test

&

Quadruple

Test.......................................5
C. Biomarker

for

Fetal

Diagnostics

Based

on

Proteomics

Platforms.......5
Amnitic
Fluid9

Monitoring Gestational-dependent Changes in the Developing

Fetus.......10
Markers

for

Preeclampsia.......10
Intra-amniotic
inflammation....11
Spontaneous Preterm Birth & Premature Rupture of the
Membranes........12
Detection

of

Chromosomal

Abnormalities...12
D. Proteomics

Techniques

used

for

Fetal

Diagnostics

&

Screening...14

Multidimensional Proteomics Approaches for Fetal Diagnostics &

Screening..14
Protein

in

Profiling

Using

MALDI-TOF-

MS.15
SELDI-TOF-MS

&

Prenatal

Diagnosis.16
Biomarker
Validation..........17
E. Expert Commentary & Five-year View : Future Directions for
Proteomics

in

Fetal

Diagnostics/Screening17
DAFTAR
PUSTAKA......19

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