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Ag
(Yoes Prijatna Dachlan, 2010)
Ag
(Stewart,2004)
Ag receptor of B lymphocytes
The structure : 4 polypeptide chains ~ 2 identical H chains ~ 2 identical L chains Arranged to span
3 structural units
binds effector molecules to trigger Ag elimination The 3rd unit (Fc) to mediate functions such as maternal-fetal transport
(Yoes Prijatna Dachlan, 2013)
(Abbas, 2012)
Model for neutralization of HIV by antibody (Ivan Roitt, Ess Immunol, 2011)
(Yoes Prijatna Dachlan, 2012)
Opsonization of bacteria
S. pneumoniae
CRO CDN
C1q
C3b CRP
SAP
Opsonization
S. pneumoniae
FcR
Phagocytosis
Opsonization of bacteria
Ag can bind in pockets or grooves or on extended surfaces in the binding sites of Abs
(Stevens, CD.,2010)
(Kuby, 2006)
(Kuby, 2006)
IgM
IgA
(Gabriel Virella, 2007, Med Immunol, 6th ed., p55) (Yoes Prijatna Dachlan, 2010)
(Kuby, 2006)
IMMUNOGLOBULIN SUPERFAMILY
B cell
CD80/CD86
CD40 D
CD28
CD40L
TCR
*
CD4
MHC Class II
ICAM-1 ICAM-3 LFA-3
LFA-1 CD2
mIg B
Signaling functions between Th B cell interaction A : TCR signal transduction B : Activation and proliferation of the B cell C : Co-stimulatory signals to the responding T cells D : Helps to drive B cells into cell cycle E : Receive signals from the T cells for division and differentiation
(Yoes Prijatna Dachlan,2010)
Mechanisms of Ab synthesis
Ehrlichs side chain hypothesis : is close to to the present view of clonal selection Dreyer & Bennett : one gene, one polypeptide dogma untenable Proved D & B hypothesis; somatic recombination
(Yoes Prijatna Dachlan, 2010)
(Janeways.ImmBiol., 2008)
(Janeways.ImmBiol., 2008)
(Stevens, CD.,2010)
Chromosome H M 22 16 2 6 14 12
Isotype switching