1 Transcribed by Erica Manion 3.27.14 Craniofacial Biology Lecture 9
Prenatal Craniofacial Development IV and V
by Dr. Wishe
Slide set: 2014 FACIAL DEVELOPMENT 4 2-23 post.ppt [Slide 12]
L FIG. 18.2 OTIC VESICLE FORMATION 11
Alright I guess we might as well continue. This is where I left off, before technical difficulties arose. And here we return to our invaginating placode, and what I was about to say before the problem happened, think of these areas as neural folds. And the two neural folds come together and when they do, you get the formation of a neural tube. But here, in terms of the ear, the two folds are coming together and eventually they fuse and you get a structure reminiscent of the neural tube but this is actually the otic vesicle. And
some folks throw in an additional term called the otic pit, that’s sort of like the opening. In addition what’s not shown on diagrams A and B, see these little yellow structures labeled
statoacoustic ganglion? Think back to the formation of the neural tube, we had neural crest
forming. The neural crest sits on top of the neural tube, and here’s your neural tube and here’s your neural crest that are fragments. Well something very similar happens in this
case. The fragmented neural crest that comes off gives rise to the statoacoustic ganglion which is associated with CN VIII. And CN VIII has dual function, one for hearing, and one for balance, equilibrium, if you will. The other thing, this is the pharyngeal area (indicated on Figure B, see image below). And the pharyngeal area seems to be getting larger and larger.
If you use imagination and just follow the sequence of diagrams, you’ll see that this
pharyngeal region comes smack up to this little indentation (in Figure C, see image below) . And this little indentation is really your first pharyngeal cleft. And all the other clefts disappear, because the mesenchyme in arch 2 grows inferiorly and all the other clefts or grooves sort of fuse into a sinus. Now what do
you think this space actually represents? The pouch. So there’s your first
pharyngeal pouch. And where the yellow is joining together with the blue, what structure do you think is going to form over here? Tympanic membrane or ear drum. This part of development of the ear seems to be far away at the moment (Image C otic vesicle), but it will come closer to this region (near the first pharyngeal cleft and pouch) and in essence the ear has an outer ear, a middle ear, and an inner ear. This otic vesicle has a dorsal and a ventral component.