Drug Generic name: Streptokinase Brand Name: Streptase Route of Administration : IV Dosage: 250,000 I !

"0 min

General Action #$rom%o&'tic en('me

Mechanism of action Acts )it$ p&asminogen to produce a ne) acti*ator comp&e+ )$ic$ en$ances t$e con*ersion of of p&asminogen to p&asmin, -&asmin t$en %eaks do)n fi%rinogen, fi%rin c&ots, and ot$er p&asma protein promoting t$e disso&ution of $e inso&u%&e fi%rin trapped in intra*ascu&ar em%o&i and t$rom%i, A&so, in$i%itors of streptokinase suc$ as a&p$a.2. macrog&o%u&in are rapid&' inacti*ated %' streptokinase,

Contraindications An' condition presenting a risk of $emorr$age, suc$ as recent surger' or %iopsies, de&i*er' )it$in /0 da's, u&cerati*e disease, Arteria& em%o&i originating from &eft of t$e $eart, A&so $epatic or rena& insufficienc', tu%ercu&osis, recent cere%ra& em%o&ism, t$rom%osis, $emorr$age, SB0, r$eumatic *a&*u&ar disease, t$rom%oc'topenia, Streptokinase resistance in e+cess of 1 mi&&ion I , se to restore patenc' to IV cat$eters,

Indications Arteria& t$rom%osis and em%o&ism, acute e*o&*ing tansmura& 2I, pu&monar' em%o&ism, c&earing of occ&uded arterio*enous and IV cannu&ae,

Side effect 2inor %&eeding at in*aded or distur%ed sites, ma3or %&eeding, fe*er, s$i*ering in acute 2I, CV: superficia& %&eeding, minor %&eeding at in*aded or distur%ed sites, Se*ere and interna& %&eeding in*o&*ing GI, G , retroperitonea& or intracere%ra& sites, Allergic: Nausea, $eadac$e, %reat$ing difficu&ties, fe*er, s$i*ering, %ronc$ospasm, angioneurotic edema, urticaria, itc$ing, f&us$ing, muscu&oske&eta& pain, *ascu&itis, interstitia& nep$ritis, respirator' depression, %ack pain

Nursing responsibilities /,Na4& in3ectioin or D55 is t$e preffered di&uent for IV use, 2, 6or AV cannu&ae, di&ute 250,000 units )it$ 2 m& of Na4& in3ection or D55, ", reconstitute gent&', a directed )it$out s$aking t$e *ia&, 7, use )it$in 27 $our of reconstitution 5, use an e&ectronic infusion de*ice to administer streptokinase and do not add an' ot$er medications to t$e &ine, Note an' redness and or pain at t$e site 8, Do not add an' medication to streptokinase, 9, Identif' ot$er drugs taking suc$ as aspirin or NSAIDs t$at cou&d increase %&eeding times,

Drug Generic name: Digo+in Brand Name: Digitek, digo+in in3ection, :ano+icaps,

General Action 4ardiac G&'coside

Mechanism of action Inceases t$e force and *e&ocit' of m'ocardia& contraction %' increasing t$e refractor' period of t$e AV node and increasing tota& perip$era&

Contraindications Ventricu&ar fi%ri&&ation or tac$'cardia;un&ess congesti*e fai&ure super*enes after protracted episode not due to digita&is<, in presence of digo+in to+icit',

Indications 4=6, inc&uding t$at due to *enous congestion, edema, d'spnea, ort$opnea, and cardiac arr$'t$mia,

Side effect #ac$'cardia, $eadac$e, di((iness, menta& distur%ances, diarr$ea, anore+ia, %&urred or 'e&&o) *ision, $'poka&emia CV: c$anges in t$e $eart rate, r$'t$m and irrita%i&it' of t$e

Nursing responsibilities /,note an' drugs prescri%ed t$at )ou&d ad*erse&' interact )it$ digo+in and monitor 2, Assess for $'per or $'pot$'roidism ", monitor *ita& signs 7, monitor )eig$s

Drug

General Action

Mechanism of action

Contraindicatio ns -ree+isting $'pertension@ occ&usi*e *ascu&ar disease@ ang&e.c&osure g&aucoma ;e'e drops<@ $'persensiti*it'@ cardiac arr$'t$mias or tac$'cardia, 5$en used in addition to &oca& anaest$etics: -rocedures in*o&*ing digits, ears, nose, penis or scrotum,

Indications

Side effect

Nursing responsibilities /, note indications for t$erap', onset, c$aracteristics of signs and s'mptoms, 2, monitor *!s ", document disease onset, su%t'pe, ot$er agents tria&ed and outcome, 7, take e+tra precaution on t$e patients )it$ fo&&o)ing conditions: 4V diseases@ $'pert$'roidism@ D2@ -arkinsonBs disease@ e&der&'@ pregnanc', &actation,

Generic Name: 0pinep$rine Brand Name: epinep$rine Amp, adrenin amp,

0pinep$rine, an Antig&aucoma acti*e princip&e of preparations t$e adrena& medu&&a, is a direct.acting s'mpat$omimetic, It stimu&ates >. and ?.adrenergic receptors resu&ting in re&a+ation of smoot$ musc&e of t$e %ronc$ia& tree, cardiac stimu&ation and di&ation of ske&eta& musc&e *ascu&ature, It is fre1uent&' added to &oca& anaest$etics to retard diffusion and &imit a%sorption, to pro&ong t$e duration of effect and to &essen t$e danger of to+icit',

Ad*anced cardiac &ife support, anap$'&actic s$ock, ocu&ar $'pertension, open.ang&e g&aucoma, ast$matic attacks

epigastric pain@ 4V disorders@ difficu&t' in micturition )it$ urinar' retention@ d'spnoea@ $'perg&'caemia@ s)eating@ $'persa&i*ation@ )eakness, tremors@ co&dness of e+tremities@ $'poka&aemia, Gangrene, tissue necrosis and s&oug$ing ;e+tra*asation< )$en used in addition to &oca& anaest$etics, 0'e drops: Se*ere smarting, %&urred *ision, p$otop$o%ia@ naso.&ac$r'ma& ducts o%struction, Aedema, $'peraemia and inf&ammation of t$e e'es )it$ repeated administration,

Drug

General Action =aemostatics

Mechanism of action As a component of a &i*er car%o+'&ase s'stem, it is in*o&*ed in t$e car%o+'&ation of t$e coagu&ation factors II ;prot$rom%in<, VII, ID and D, and of t$e coagu&ation in$i%itors protein 4 and protein S in t$e post.ri%osoma& p$ase, Anticoagu&ants of t$e dicoumaro& t'pe in$i%it reduction of *itamin C/ ;1uinone form< to *itamin C/ $'dro1uinone and a&so pre*ent t$e *itamin C/ epo+ide )$ic$ arises after t$e car%o+'&ation reaction from %eing reduced to t$e 1uinone form, -$'tomenadione is t$us an antagonist of 2arcouman and simi&ar anticoagu&ants, It does not, $o)e*er, in$i%it t$e action of $eparin@,

Contraindications ='persensiti*it' to an' of t$e constituents of Conakion 22!22 -ediatric, -ronounced a&&ergic diat$esis,

Indications =emorr$age or t$reatened $emorr$age as a resu&t of se*ere $'poprot$rom%i nemia ;ie, deficienc' of coagu&ation factors II, VII, ID, D< due, for instance, to o*erdosage of anticoagu&ants of t$e dicoumaro& t'pe or t$eir com%ination )it$ p$en'&%uta(one or to ot$er forms of $'po*itaminosis C@ -rop$'&a+is and treatment of $emorr$agic disease of t$e ne)%orn,

Side effects se*ere, s$ock. &ike reactions, In rare cases, anap$'&actoid reactions $a*e %een reported after parentera& use of konakion 22 -ediatric, :oca& irritation ma' occur at t$e in3ection site, %ut is un&ike&' due to t$e sma&& in3ection *o&ume,

Nursing responsibilites /, #$e /0 mg!m: mi+ed.mice&&e ampou&e must not %e gi*en to infants E/ 'ear o&d 2, -arentera& administration ma' %e associated )it$ an increased risk of kernicterus in premature infants )eig$ing E2,5 kg, ", At t$e time of use, t$e ampou&e so&ution must %e c&ear, Improper storage can cause tur%idit' or p$ase separation, In t$is case, t$e ampou&e must not %e used,

Generic Name: Conakion Brand Name: Conakion 22 Route of administration: -arentera&, ora& Dosage: Therapy: /0 mg ;up to 20 mg< Ara&: 2 mg

Drug

General Action Nonsteroida& anti. inf&ammator'

Mechanism of action -osseses anti. inf&ammato', ana&gesic, and antip'retic effects

Contraindications

Indications

Side ffects

Nursing !esponsibilities /, use as a part of a regu&ar ana&gesic sc$edu&e rat$er t$an on an as. needed %asis 2, if gi*en p,r,n, %asis, %ase si(e of repeat dose, If pain returns )it$in ".5 $r, t$e en+t dose can %e increased %' up to 50 percent ", s$ortening t$e dosing inter*a&s recommended )i&& &ead to an increased fre1uenc' and duation of side effects,

Generic Name: Cetoro&ac tromet$amine Brand Name: Acu&ar Route of Administration I2, IV, -A, op$t$a&mic Dosage: 80 mg for &ess t$an 85 'ears o&d, I2 "0 mg for IV 80 mg -A /gtt 7+ a da' for op$t$a&mic route

='persensti*t' to t$e drug or a&&ergic s'mtpms to aspirin or ot$er NSAIDs, Acti*e peptic u&cer disease, recent GI %&eeding or perforatin, $istor' of peptic u&cer disease, ad*anced rena& impairment and in t$ose at risk for rena& fai&ure due to *o&ume dep&etion, suspected or confirmed cere%ro*a+cu&a %&eeding, $emorr$agic diat$esis, or incomp&ete $emostasis and in t$ose )it$ $ig$ risk of %&eeding,

Se*ere, acute pain in adu&ts, itc$ing caus(ed %' seasona& a&&ergic con3uncti*itis, , post operati*e inf&ammation fo&&o)ing cataract surger', reduce ocu&ar pain, %urining and stinging after cornea& refracti*e surger', reduction of ocu&ar pain and p$otop$o%ia fo&&o)ing incisiona& refracti*e surger',

=eadac$e, di((iness, rdro)siness, diarr$ea, nausea, d'spepsia, indigestion, epigastric pain, edema, transient %urning stinging upon administration, ocu&ar irritation,

Drug

General Action

Mechanism of Action #$e ana&gesic effect is on&' partia&&' antagoni(ed %' t$e antagonist na&o+one, 4auses significant&' &esss respirator' depression t$an morp$ine, In contrast to morp$ine, tramado& does not cause re&ease of $istamine, -roduces dependence of t$e mu.opioid t'pe $o) e*er t$ere is &itt&e e*idence of a%use, #o&erance occurs %ut is re&ati*e&' mi&d@ t$e )it$dra)a& s'ndrome is not as se*ere as )it$ ot$er opiates

Contraindications

Indications

Side ffects

Nursing responsibilities /,do not confuse &tram )it$ &trase 2, :ist easons for t$eap', &ocation, onset, trigges, c$aracteristics of S and S, use a pin. rating sca&e to rate pain, ", Assess for $istor' of drug addiction, a&&erg' to opiates or codeine, sei(ures@ drug ma' increase t$e risk of con*u&sions 7, 2onitor VS, Iand A, rena& and :6#s, reduce dose )it$ d'sfunction and if o*er 95 'ears o&d,

Generic Name: #ramado& $'droc$&oride Brand name: &tram, &tram 0R Route of administration: Ara& Dosage: 50./00mg 1 7.8 $r prn

Ana&gesic

='persensiti*it' to tramado&, in acute into+ication )it$ a&co$o&, $'pnotics, centra&&' acting ana&gesics, opiates or ps'c$otropic drugs, se in c&eitns )it$ past r resent addictin or opiate dependence or in t$ose )it$ a prior $istor' of a&&erg' to codeine or opiates, se for o%stetric preoperati*e medicatin of postde&i*er' ana&gesia In nursing mot$ers,

2oderate to moderate&' se*ere pain,

Di((iness, $eadac$e, 4NS stimu&ation, ata+ia, sedation, *ertigo, itc$ing, constipation, nausea, sei(ures, parest$esia, cogniti*e d'sfunction, $a&&ucinations, tremor, amnesia, concentration difficu&t', a%norma& gait, migraine, nausea, constipation, *omiting, d'spepsia, dr' mout$, diarr$ea, anore+ia

Drug

General action

Mechanism of Action =ig$ sedati*e, antic$o&inergic, and antiemetic effects

Contraindication

Indication

Side ffect

Nursing responsibilities /, note reasons fo t$erap', signs and s'mptoms of c$aractgeristics, ot$er agents tria&ed, triggers, outcome 2, do not confuse dip$en$'dramine )it$ desipramine )it$

Generic Name: anti$istamine Dip$en$'drami ne =4& Brand Name: Benadr'& Route of administration:

-remature F ne)%orn infants@ ast$ma attack@ &actation,

=a' fe*er, urticaria, *asomotor r$initis, angioneurotic edema, drug sensiti(ation, serum F penici&&in reaction, contact dermatitis, atopic ec(ema, ot$er

4V F 4NS effects, B&ood disorders, GI distur%ances, Antimuscarinic effects, A&&ergic reactions, Dro)siness, constipation, diarr$ea, di((iness, dr' mout$, nose,

Drug

General Action 4a&cium c$anne& %&ocker

Generic Name: Nifedipine Brand Name: 4a&ci%&oc Route of administration: Ara& Dosage: 4apsu&es: /0.20 mg "+ a da' #a%&ets: "0.80 mg per da'

Mechanism of action , It %&ocks t$e ca&cium or Gs&o)G c$anne&s and in$i%its entr' of ca&cium ions into *ascu&ar smoot$ musc&es particu&ar&' of resistance *esse&s and coronar' arteries, di&ates coronar' and perip$era& arteries, as )e&& as *eins, 4oronar' arteria& *asodi&ation increases coronar' %&ood f&o) in t$e isc$emic post. stenotic areas, )$i&e di&ation of t$e perip$era& arteries &o)ers arteria& %&ood pressure and reduces &eft *entricu&ar after&oad, Some rena& arter' di&atation ma' stimu&ate mi&d diuresis,

Contraindicatio ns 4ardio*ascu&ar s$ock, se*ere aortic stenosis or in patients kno)n to %e $'persensiti*e to nifedipine, 4are is needed in patients )it$ *er' &o) %&ood pressure ;se*ere $'potension )it$ s'sto&ic pressure EH0 mm=g< or decompensated $eart fai&ure,

Indications A&& forms of $'pertension, primar' or secondar', Nifedipine is most effecti*e for mi&d to moderate degrees of $'pertension %ut t$e capsu&e ma' %e %itten and s)a&&o)ed for more rapid effects as in $'pertensi*e crises, ='pertension in pregnanc' ;at an' term of pregnanc'<, 4oronar' insufficienc' )it$ or )it$out angina. Vasospastic angina ;-rin(meta&Bs angina<, #o increase $eart rate in patients )it$ sinus %rad'cardia and sick.sinus s'ndrome,

Side ffects Side effects are mi&d, transient and re&ati*e&' infre1uent, #$ese inc&ude f&us$ing, nausea, di((iness, $eadac$e, tiredness, sedation, &eg edema and ot$er manifestations of perip$era& *asodi&ation,

Nursing !esponsibilities /, dot not confuse nifedipine )it$ nicardipine 2, do not e+ceed a sing&e dose ", %efore increasing dose, carefu&&' monitor B7, use on&' t$e sustained re&ease ta%&ets to treat $'pertension 5, concomitant t$erap' )it$ %eta renergic %&ocking agents ma' %e used 8, c&ients )it$dra)n from %eta %&ockers ma' manifest s'mptoms of increased angina )$ic$ cannot %e pre*ented %' nifedipine@ in fact nifedipine ma' increase t$e se*erit' of angina situation

PAMANTASAN NG CABUYAO
Katapatan Vill, Banay-banay, Cabuyao, Laguna

AGNES D. CABINTOY IVN2- G OUP!