Clinical Symptoms;

1. 2. Abnormal bleeding Bleeding into major clinical manifestations in myoma and it occurs in 30% of patients. Pain Myomas do not cause pain in the uterus unless the later vascular disruption. Symptoms and signs of suppression This interference depends on the large and the myoma uteri. Emphasis on the bladder will cause polyuria, the urethra can cause urinary retention, the ureter may lead to hydroureter and hydronephrosis, the rectum can cause obstipasi and tenesmia, the blood vessels and lymph vessels can cause edema draped limbs and pelvic pain. Infertility and abortion Infertility can occur when close or suppress uterine nest pars intertisialis tuba, while myomas submukosum also facilitate abortion because the uterine cavity distortion.

3.

4.

PATOFISIOLOGY
The exact etiology of myoma uteri until now unknown. Suspected estrogen stimulation was instrumental to the occurrence of myoma uteri. This hypothesis is supported by the presence of uterine myomas that are found in the low incidence of reproductive age and the age of menopause. Ichimura said that ovarian hormones believed to stimulate uterine growth due to an increased incidence after menarche. In pregnancy the greater the growth of this tumor, but decreases after menopause.

Pukka and colleagues reported that uterine myoma tissue contains more estrogen receptors when compared with normal myometrium. Uterine myoma growth varies between individuals. This difference is related to the number of estrogen receptors and progesterone receptors.