DEPARTEMEN PATOLOGI ANATOMI FAKULTAS KEDOKTERAN UMI - UHN

caused by papillomavirus transmitted from one site to anotherand one person to anotherby direct contact. the fingers are the most common single site.

Histologically : The wart is a squamous papilloma with variable keratinization and conspicuous keratohyaline granules. Large vacuolated cells in the proliferating squamous epithelium stain positively for papilloma virus by the immunoperoxidase technique.

Caused by virus of the poxvirus group. Lesions consist of small and discrete domeshaped papules that have an umbilicated center. Heal spontaneously. Histologically : The epidermis bulges downward into the dermis and the epidermal cells contain intracytoplasmic inclusion bodies molluscum bodies.

Very common lesion. Occurring on the trunk, extremities and face. Usually in elderly persons. Lesions are flat, raised, soft, sharply demarcated, and brown. Seborrheic keratosis is benign and probably not a true neoplasm. Histologically : Seborrheic keratosis is a flat, often pigmented squamous epithelial proliferation with many keratin-filled cysts (horn cysts).

Occurs in middle age. Commonly on the face or upper extremities. Characterized by a rapid early growth phase, reaching maximum size in a few weeks, followed by a static phase (up to 1 year) after which the lesion spontaneously involutes with scarring.

Histologically : keratoacanthoma appears as a cup-shaped lesion with an irregular keratin-filled crater in the center. Though resembling invasion, the base of the lesion is smooth and does not penetrate deeper than the level of the hair follicles. The cells frequently show mild atypia, mitotic activity, and dyskeratosis, making histologic distinction from squamous carcinoma difficult.

The term nevus (Latin naevus, mole) is used in a general sense for many cutaneous lesions present at birth. Melanocytic nevi are usually not present at birth but appear in childhood and stop growing soon after puberty. They are benign and present clinically as flat, papular, papillomatous or pedunculated pigmented (black or brown) lesions. If a nevus changes its form in any way, malignancy should be suspected.

Histologically : Moles are composed of nests of nevus (melanocytic) cells, which may be found in the dermis (intradermal nevus), at the junction between epidermis and dermis (junctional nevus), in both locations (compound nevus).

Junctional activity (melanocytic proliferation in the junctional zone) usually decreases after puberty. If it is prominent in an older patient or associated with cytologic atypia, malignant melanoma should be considered. In young patients, compound nevi may show marked cytologic atypia, pleomorphism, and junctional proliferation (Spitz nevus) with no implication of malignant behavior.