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367
S. Faubel and J. Topf14 Metabolic Alkalosis
14
14 Metabolic Alkalosis
 
368
The Fluid, Electrolyte and Acid-Base Companion
Metabolic alkalosis is characterized by an increased plasma bicarbonateand an increased pH. After buffering and respiratory compensation, the P
CO
2
is also increased.
Primary metabolic alkalosis is a process characterized by a(n)____________ (increase/decrease) in plasma bicarbonate.In metabolic alkalosis the pH, bicarbonate and P
CO
2
are all____________ (increased/decreased).aaaincreaseincreased
Introduction
Metabolic alkalosis is characterized by an in-creased plasma bicarbonate.
pH
HCO
3 –
CO
2
pH
HCO
3 –
CO
2
pH
HCO
3 –
CO
2
pH
HCO
3 –
CO
2
METABOLIC
 
ALKALOSISRESPIRATORY
 
ALKALOSISRESPIRATORY
 
ACIDOSISMETABOLIC
 
ACIDOSIS
 
369
S. Faubel and J. Topf14 Metabolic Alkalosis
Loss ofhydrogenContractionalkalosis
The development of metabolic alkalosis is a two-step process: generationand maintenance.
The generation
of metabolic alkalosis is through processes which in-crease plasma bicarbonate. Plasma bicarbonate can increase via three mecha-nisms:addition of bicarbonatecontraction alkalosisloss of hydrogen
The maintenance
of metabolic alkalosis is always due to the inability of the kidney to excrete excess bicarbonate.
Introduction
The development of metabolic alkalosis includesboth generation and maintenance.
The development of metabolic alkalosis is a(n) _______-stepprocess: generation and _____________.The maintenance of metabolic alkalosis is always due to the in-ability of the kidney to excrete excess ___________.twomaintenancebicarbonate
HCO
3
HCO
3
HCO
3
HCO
3
Addition ofbicarbonateInability to excreteexcess bicarbonate
GenerationMaintenance
H   C   O   
3   
H   C   O   
3   
   H  C  O
   3
     H     C     O
    3
HCO
3
 
   H  C  O
  3
 
H  
7654321
 H C O
 3
H  
 
H
+
H
+
H
+

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