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Terbinafine Hydrochloride:
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Terbinafine Hydrochloride - Pharmacological action - antifungal, fungicidal. Are affected, yeastlike and moldfungi. It strikes the cytoplasmic membranes of fungus cells, it specifically inhibits and it disrupts the synthesisof ergosterol, causing fungicidal effect. It is active with respect to practically all fungi, pathogenic for the man,but most of all - red (minimum inhibiting concentration it is 0,001-0,06 g/ml) and pathogenic yeast(s) - mold,also of the mycelial forms of the kind of Candida.Because of the Terbinafine Hydrochloride's effect “first passage” compose about 40%. Cmax - 1 g/ml, isreached for 2 h after method at the dose of 250 mH. In the vascular channel practically completely (to 99%) itis connected with the proteins of plasma. Histohematic barriers are passed and it is distributed along thecloths; high concentrations are accumulated in the skin (in such cases in the sebaceous glands and hair follicles) and subcutaneous cellular tissue. It is characterized by expressed by epidermis and By 2-1 daysafter method 250 mH the concentration in the horny layer of the skin grows 10, by the 12th day - 70. Thediffusion rate exceeds the rate of growth in the nail. 1/2 of terminal phase is 200-400 h. Before the excretion it
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