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Apoptosis andCancer
 
What is Apoptosis?
•
Apoptosis is “programmed cell death”.
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Apoptosis is a normal physiological process:
 –
Foetal development: finger and toe development requires loss of tissue between.
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Removal of endometrium at menstruation.
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Formation of synapses in brain requires loss of surplus cells.
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Apoptosis is need to remove cells that pose a threat:
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Cytotoxic T lymphocytes kill viral infected cells by inducingapoptosis.
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Effector cells of the immune system must be removed after theresponse.
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Damaged cells must be removed if they cannot be repaired.
 
Apoptosis
•
 Apoptosis
from Greek, meaning
“to fallaway from.” 
•
 The release of apoptotic bodies fromcells is supposed to be analogous to
“leaves falling from trees.” 
 
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Pronounced A-po-toe-sis
of 00

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