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Safety
The ImSAIDs® are comprised of naturalamino acids that have demonstrated notoxicity or immune suppression in numerousanimal studies, including dogs, cats, and avariety of other species
ImSAIDs® - Cellular Modulation
in vivo
and
in vitro
results have shown theImSAIDs® to help support the following:
 
reduce granulocyte ac
t
va
t
on andchemotaxis
 
diminish oxida
t
ve burst capacity and theproduc
t
on of reac
t
ve oxygen species
 
a
enuate the e
ff 
ects of endotoxin, andreduce allergic & anaphylac
t
c reac
t
ons(type I hypersensi
t
vity and IgE-mediatedreac
t
ons)
Additional References on ImSAIDs®
Immunopharmacology
Mathison R, et al.Modula
t
on of neutrophil func
t
on by thetripep
t
de feG.
BMC Immunol.
2003 Mar 4;4:3. 2003Mathison R, et al.Regula
t
on of leukocyte adhesion to heart by thetripep
t
des feG and feG(NH2). Can
J Physiol Pharmacol
. 2001 Sep;79(9):785-92.Mathison RD and Davison JS.The Tripep
t
de feG Regulates theProduc
t
on of Intracellular Reac
t
ve Oxygen Species by Neutrophils.
JInamm
(Lond). 2006 Jun 15;3(1):9Mathison R, Davison JS, Befus AD.Neuroendocrine regula
t
on of in
fl
amma
t
on and
t
ssue repair by submandibular gland factors
.Immunol Today.
1994 Nov;15(11):527-32.Mathison RD, et al.The tripep
t
de feG inhibits leukocyte adhesion
. JInamm
(Lond). 2008 May 20;5:6.Mathison R, Davison JS.Molecular characteris
t
cs of the tripep
t
defeG accoun
t
ng for di
ff 
erent biological ac
t
vi
t
es.
Proc WestPharmacol Soc
. 2007;50:101-4.Mathison RD, et al..A pep
t
de from the submandibular glandsmodulates in
fl
ammatory responses
. Int Arch Allergy Immunol
. 1997May-Jul;113(1-3):337-8.Mathison RD, et al.Submandibular glands: novel structurespar
t
cipa
t
ng in thermoregulatory responses.
Can J PhysiolPharmacol.
1997 May; 75(5):407-13.
leukoSTAT™ (ImSAIDs® Enabled)
leukoSTAT™ contains the ImSAIDs®;patented amino acid complexes thatmaintain systemic health, by aiding in thereduc
t
on of leukocyte ac
t
va
t
on andchemotaxis.
 
ImSAIDs® are
Not
COX/LOXinhibitors or steroids, but naturallyoccuring amino acid complexes that naturedesigned to posi
t
vely i
nfl
uence theimmune system, including leukocytes.
leukoSTAT™ Product & Ordering
IMULAN has developed a highly palatable,chewable tablet for dogs and cats. Thesmall, 625mg chewable tablet can be usedwhen only small amounts of material canbe given orally. leukoSTAT™ is available in30 and 120 count bo
les.To purchase LeukoSTAT™; please go to
www.IMULAN.com
and set up an account.You may also contact IMULAN at
info@imulan.com
IMULAN BioTherape
ut
cs4221 Mitchell AvenueSt. Joseph, MO 64507www.IMULAN.com
480-248-2176
.
Immuno-Nutri
t
onalTechnology
 
ALL Inammation is Regulatedby Leukocytes 
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