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As a result ,person with XP are extremely sensitive to sunlight Even very limited exposure to the direct rays of the sun can produce large numbers of dark-pigmented spots on exposed areas of the body and a greatly elevated risk of developing disfiguring and fatal skin cancers.
Once TT is formed, ultraviolet radiated DNA will not be repaired correctly. The replication and the transcription of DNA will be influenced seriously.
In persons with XP who carry specific mutations in the XPD gene. XPD gene encodes a subunit of the TFII H required for transcription initiation() So, Mutations in XPD could lead to defect() in both DNA repair and transcription
The enzyme are contained in liposomes() that can apparently penetrate () the outer layer of the skin and participate in repair pathways
XP is a very rare condition ,but colon cancer( ) is relatively common. It is estimated that up to 15 percent of colon cancer cases can be attributed to mutations in the genes that encode the proteins required for mismatch repair.
Mutations that cripple the mismatch repair system inevitably lead to higher mutation rate in other genes because mistakes made during replication are not corrected.