What is Triple-X Syndrome?

Triple-X Syndrome is a genetic disorder characterized by the presence

of an additional X chromosome in each of a females cell. Only occurs in females. Females have 3 X chromosomes instead of 2. Affects approximately 1 in every 1000 females. A girl with triple X syndrome may either have no symptoms, just mild ones, or more severe ones with developmental delays. Developmental delays may include learning disabilities, delayed development of speech and language skills, as well as motor skills. 10% of affected females have seizures or kidney abnormalities.

Symptoms
Tall stature Vertical skin folds that may cover the inner corners of the eyes

(epicanthal folds) Delayed development of speech and language skills Weak muscle tone (hypotonia) Curved pinky fingers (clinodactyly) Behavior and mental health problems Premature ovarian failure or ovary abnormalities Constipation or abdominal pains

Triple-X Syndrome is not inherited, but usually occurs from a mistake during the formation of the fathers sperm cell or the mothers egg.

This mistake is called nondisjunction which is the failure of chromosome pairs to separate properly during Meiosis 1 and 2.
Can also occur from something going wrong during the development of the embryo.

Problems in Male Meiosis

This results in a mosaic form of Triple-X Syndrome where there is a presence of two or more populations of cells with different genotypes.

Problems in Female Meiosis