This short monograph is a compilation of representative protocols that have been used in our clinicsto desensitize patients who met generally accepted criteriafor a diagnosis of drug allergy. The purpose of presentingthis information is to facilitate the design of protocols for use by other clinicians or investigators.Approaches to patient specific diagnosis of drugallergy, assessment of relative risks, decisions about premedication, and other patient specific factors crucial tosuccessful use of these protocols is beyond the scope of thismonograph.
protocols have been usedto allow use of medications in patients with IgE-mediatedsensitivity to medications. The mechanism seems to be primariy acute antigen-specific mast cell desensitization.The general principles are to initiate desensitization withlow microgram amounts of drug, doubling the dose every15 minutes, and then careful observation for 2 hours after the administration of the last dose. Individual patients mayrequire lower starting doses and longer intervals betweendoses. Representative oral desensitization and intravenousdesensitization protocols are presented. Code 95180 per hour of the procedure to the nearest hour.
protocols are used for management of patients with drug allergy involving