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Pharmacokinetics
Definition 
-Pharmacokinetics (in Greek:
〝
pharmacon
〞
meaning drug and
〝
kinetikos
〞
meaning putting in motion , the study of timedependency) is a branch of pharmacology dedicated to thedetermination of the fate of substances administered externallyto a living organism.
 
-Pharmacokinetics is the study and characterization of the timecourse of drugabsorption,distribution,metabolismandexcretion. This sometimes is referred to as theADMEscheme.- Pharmacokinetics also concerns the relationship of the processesto theintensityandtime courseof therapeutic andtoxicologic  effects of drugs.
 
 
Pharmacokinetics (ADME)
 
 
1.Sampling of biological speciments
--Invasive methods: Blood, spinal fluid, tissue biopsy.--Non-invasive methods: Urine, salive, feces, expired air 
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Measurement of drug concentration in the blood, serum or plasma is the most directapproach to assess the pharmacokinetics of drug in body.
2.Significance of measuring plasma drug concentration
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The intensity of the pharmacologic or toxic effect of a drug is oftenrelated to theconcentrationof the drug at the receptor sites.
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Monitoring the concentration of drugs in the blood or plasma ascertainsthat the calculated dose actually delivers the plasma level required for therapeutic effect.
Measurement of drug concentration
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