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Absorption of Drugs

Absorption of Drugs

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Published by alexpharm

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Categories:Types, Research
Published by: alexpharm on Nov 05, 2009
Copyright:Attribution Non-commercial


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-Pharmacokinetics (in Greek:
meaning drug and
meaning putting in motion , the study of timedependency) is a branch of pharmacology dedicated to thedetermination of the fate of substances administered externallyto a living organism.
-Pharmacokinetics is the study and characterization of the timecourse of drugabsorption,distribution,metabolismandexcretion. This sometimes is referred to as theADMEscheme.- Pharmacokinetics also concerns the relationship of the processesto theintensityandtime courseof therapeutic andtoxicologic  effects of drugs.
Pharmacokinetics (ADME)
1.Sampling of biological speciments
--Invasive methods: Blood, spinal fluid, tissue biopsy.--Non-invasive methods: Urine, salive, feces, expired air 
Measurement of drug concentration in the blood, serum or plasma is the most directapproach to assess the pharmacokinetics of drug in body.
2.Significance of measuring plasma drug concentration
The intensity of the pharmacologic or toxic effect of a drug is oftenrelated to theconcentrationof the drug at the receptor sites.
Monitoring the concentration of drugs in the blood or plasma ascertainsthat the calculated dose actually delivers the plasma level required for therapeutic effect.
Measurement of drug concentration

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