Pathophysiology

Risk Factors:
Non-Modifiable: Age(newborn)
Modifiable: Uninstitutionalized delivery, Environment

Infection

Systemic Inflammatory Response Syndrome

Response to a wide variety or clinical insults:
-hyperthermia
-tachycardia
-tachypnea
-increased WBC

Sepsis
SIRS with hypotension in response to infection

Severe Sepsis
Sepsis with organ dysfunction, hypoperfusion or hypotension.
May include change in mental status, oliguria, hypoxemia, or
lactic acidosis.

Septic Shock
Severe sepsis with persistent hypotension despite adequate
fluid resuscitation

Multiple Organ Dysfunction Syndrome

Presence of altered organ function such that homeostasis
cannot be maintained without intervention.
 The Septic Process

Focus of
Infection

ACTH / Endorphins
Release
Bacterial
cell wall
products

Primary Complement
Mediators system
Coagulation system (TNF,IL-1, activation
activation IFN,Others)

PNM
Endothelial/ Stimulation
Leukocyte
Molecular
Kallikrein- activation
kinin
Stimulation

Secondary Capillary leak

Mediators (PAF, and endothelial
eicosanoids, damage
Other
Vasodilation and interleukins,etc.
endothelial )
damage

SHOCK

MODS

DEATH