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Recommendation Letter for XU ZHI

Recommendation Letter for XU ZHI

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Published by: zhixujp on Nov 14, 2009
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November 15, 2009DOD Breast Cancer Postdoctoral Fellowship AwardProgram Review CommitteesDear Review Committee Members:It is my great pleasure to write this letter inrecommendation of Dr. Xu Zhi for supporting herapplication of DOD Breast Cancer Postdoctoral FellowshipAward, as she is an excellent researcher withextraordinary scientific ability.I am the Professor/Chairman of the Department ofObstetrics and Gynecology in Osaka City UniversityGraduate School of Medicine, Osaka, Japan. Dr. Zhigraduated from China Medical University in 1999, and thenworked as a medical doctor in Beijing, China until shecame to our department in Japan. She has been worked onher Ph.D. degree from April 2004 to March 2008 here, andI was deeply impressed by Dr. Zhi’s scientific abilityand highly self-motivated research attitude.During the Ph.D. course, Dr. Zhi has accumulatedabundant experience on gynecological cancer research. Sheaimed at the molecular mechanisms underlying endometrialcancer, which is the most common malignant tumor of thefemale genital system in developed countries. She hopesto find out the characteristic alterations of geneexpression in endometrial cancer, which could be helpfulto elucidate the pathogenic and therapeutic interventionof endometrial cancer. She adopted a rare endometrialcancer cell line (HHUA) expressing the estrogen receptor,and investigated the angiogenesis- and apoptosis-relatedgenes based on quantitative real-time RT-PCR assays. Thisstudy showed the characteristic gene expression of VEGFand Bcl-2 and, for the first time revealed the fact thatERα and ERβ expression in HHUA cells was converse to thatin normal endometria, which should be taken into

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