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Anemia Megaloblastica

Anemia Megaloblastica

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Published by Rosulescu Corneliu
Hematologie
Hematologie

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Published by: Rosulescu Corneliu on Jun 02, 2014
Copyright:Traditional Copyright: All rights reserved

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03/23/2015

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 Anemiile megaloblastice
 
Definitie
Sinteza deficitara a ADN-ului, ce induce diviziune celulara lenta, care afecteaza celulele cu turnover rapid, in special maduva hematogena si epiteliul gastrointestinal.
 Megaloblastii 
 
 –
 celule de talie mare, caracterizate prin sinteza deficitara a ADN-ului, in timp ce sinteza de ARN este normala
 tipic:
asincronism nucleo-citoplasmatic 
: nucleu imatur, mare, cromatina fina; citoplasma matura, normal incarcata cu hemoglobina.
 Anemii macrocitare hiporegenerative
 
Clasificarea anemiilor
Volumul eritrocitar:
Microcitara
 –
 VEM < 80fl
Normocitara
 –
 VEM = 80-100fl
Macrocitara
 –
 VEM > 100fl
Raspunsul medular:
Regenerativa (maduva compenseaza deficitul
reticulocitoza)
 Aregenerativa (raspuns medular deficitar)

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