PREGELATI NI ZED STARCH PROCESS FROM CASSAVA

STARCH (Manihot esculenta Crantz) AS A DI SI NTEGRANT

AGENT OF TABLETS USI NG WET GRANULATI ON METHOD
WI TH PYRI DOXI NE HCl AS AN ACTI VE AGENT


By
SYSKA VIANTIKA
21091138


ABSTRACT

Cassava starch (Manihot esculenta Crantz) in the pharmaceutical
industry as a tablet excipiens, such as a filler, binder, and
disintegrant. In the process, the starch could be modified in several
ways to improve the physicochemical properties, one of them is pre-
gelatinization process. The aim of this research was to improve the
physical properties of Pyridoxine HCl tablets the use of
pregelatinized cassava starch as disintegrant with use wet
granulation method. Pregelatinized starch made by various
temperature 60
o
C, 65
o
C, and 70
o
C then continued by testing the
pregelatinized starch granules. In this study created 4 formulas
consisting of formula 1 (using 60
o
C pregelatinized starch), formula 2
(using 65
o
C pregelatinized starch), formula 3 (70C using
pregelatinized starch) and formula 4 (using amprotab). The results
showed that the use of pregelatinized cassava starch at temperature
60C, 65C, and 70C and amprotab as disintegrant with used wet
granulation method do meet the requirements physical properties of
a good tablet. Formula 4 had a disintegration time of 7 minutes 50
seconds faster than a formula 1 is 8 minutes 47 seconds, formula 2 is
8 minutes 53 seconds, and the formula 3 is 9 minutes 47 seconds.

Key words: Cassava Starch, Pregelatinized, Disintegrant.