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Lecture #10. the Biology of Cancer, p53

Lecture #10. the Biology of Cancer, p53

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Published by cafemed

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Published by: cafemed on Nov 24, 2009
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01/09/2013

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Lecture #10
.
The biology of Cancer, p53
Axiom #10
Learn to cope with
constructive
criticism.This isn’t always easy, but it is necessary for success
138906
HeLa cancer cells
 
Cancer is an umbrella term covering a plethora of conditions characterized by unscheduled anduncontrolled cellular proliferation.
Almost any mammalian organ and cell type can succumb to oncogenictransformation, giving rise to a bewildering array of clinical outcomes.The causes of cancer are many and varied, and include genetic predisposition, environmental influences, infectious agents and ageing.These transform normal cells into cancerous ones by derailing a widespectrum of regulatory and downstream effector pathways. It is justthis complexity that has hampered the development of effective andspecific cancer therapies.Any attempt to provide a comprehensive overview of cancer-relatedknowledge would be futile — therefore the next two lectures willfocus on topics undergoing particularly rapid progress.
 
Cancer Incidence and Death Rate
Fig. 16.2

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