Copyright 2008 The Endocrine Society

Kondrashova, A. et al. J Clin Endocrinol Metab 2008;93:729-734

FIG. 1. Frequency of TPOAb and TGAb in schoolchildren in Russian Karelia (black bars)
and in Finland (white bars)
Copyright 2008 The Endocrine Society
Checchi, S. et al. J Clin Endocrinol Metab 2008;93:465-469
FIG. 2. L-T4 requirement ({micro}g/kg {middle dot} d) in hypothyroid patients on L-T4
replacement therapy according to the PCA status (positive or negative)
TABLE 1. Clinical features of hypothyroid patients with autoimmune thyroiditis according to PCA status




PCA
+
PCA

P
n
155 236
Sex (male/female)
1/9 1/9
BMI (kg/m
2
) 26.1 4.7 25.4 4.6
0.18
Age (yr) 57.4 14 53.9 14.9
0.06
Time from diagnosis on L-T
4

(months)
93.1 82.1 90.6 67.1
0.92
Pretherapy serum TSH levels 17.9 22.9 21.7 35.0
0.78
Thyroid volume at diagnosis
(ml)
10.5 9.3 8 5
0.8
Serum TSH (U/ml) 1.5 0.7 1.5 0.7
0.28
Serum FT
3
(pg/ml) 2.9 0.47 2.9 0.44
0.45
Serum FT
4
(pg/ml) 13.5 2.4 13.8 2.6
0.32
Serum PCA (U/ml)
Mean SD
84 91 4.4 3.4
<0.0001
Range
14.5489 0.214
Table 1: Clinical features of hypothyroid patients with autoimmune thyroiditis
acording to PCA status
Copyright 2008 The Endocrine Society
Checchi, S. et al. J Clin Endocrinol Metab 2008;93:465-469
FIG. 3. L-T4 daily requirement in 73 PCA-positive patients submitted to gastric biopsy
according to the histological results (normal mucosa or atrophic changes)
TABLE 1. Clinical characteristics and androgen levels of the PCOS and
control groups



PCOS (n = 83) Controls (n = 39) P value
Age (yr) 27.8 4.7 27.8 5.6
0.785
BMI (kg/m) 30.4 5.9 29.1 4.8
0.140
WHR 0.82 0.07 0.80 0.04
0.191
Testosterone (nmol/liter) 2.21 1.44 1.32 0.62
<0.001
FT (pg/ml) 2.41 1.31 1.10 0.58
<0.001
DHEAS (mol/liter) 5.0 2.7 5.8 2.2
0.035
Androstenedione
(ng/ml)
3.61 1.43 2.69 1.10
0.001
SHBG (nmol/liter) 36.2 21.4 49.0 25.8
<0.001
FAI 8.51 7.93 3.18 1.68
<0.001
FSH (IU/liter) 5.9 2.6 5.9 2.3
0.686
LH (IU/liter) 9.5 7.7 4.5 3.7
<0.001
Ferriman-Gallwey score 6.3 3.8 1.3 0.7
<0.001
Karavitaki N, Trifanescu R, Wass J, Clin Endocrinol, 2006; 65:524
Karavitaki N, Trifanescu R, Wass J, Clin Endocrinol, 2006; 65:524
Cumulative Kaplan-Meier Estimates of the Rates of Key
Study End Points during the Follow-up Period

Wiviott S et al. N Engl J Med 2007;357:2001-2015
Mean ({+/-}SE) Percentage Change from Baseline to 1 Year
in Glycated Hemoglobin, Fasting Plasma Glucose,
Postprandial Glucose, and Body Weight (Panel A) and Mean
(+SD) Hypoglycemic-Event Rate (Panel B)
Holman R et al. N Engl J Med 2007;357:1716-1730
Holman R et al. N Engl J Med 2007;357:1716-1730
Adverse Events
Copyright 2007 The Endocrine Society
Misra, M. et al. J Clin Endocrinol Metab 2007;92:4623-4629
FIG. 1. Glucose and log GH levels after
an oral glucose load in prepubertal girls
(A) (group 1: Tanner 1),
early to midpubertal girls (B) (group 2:
Tanner 2 and 3),
mid to late pubertal girls (C) (group 3:
Tanner 4 and 5),
prepubertal and early pubertal boys (D)
(group 1: Tanner 1 and 2),
midpubertal boys (E) (group 2: Tanner 3
and 4), and late pubertal boys (F) (group
3: Tanner 5)