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Environmental Safety of Active Pharmaceutical Ingredients

Environmental Safety of Active Pharmaceutical Ingredients

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Published by Manju Mudakavi

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Published by: Manju Mudakavi on Nov 26, 2009
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07/01/2011

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Dr. Richard ReissDr. Richard ReissSciences International, Inc.Sciences International, Inc.October 20, 2005October 20, 2005
Environmental Safety of ActiveEnvironmental Safety of ActivePharmaceutical IngredientsPharmaceutical Ingredients
 
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IntroductionIntroduction
Talk will focus on triclosan (TCS) andTalk will focus on triclosan (TCS) andtriclocarban (TCC)triclocarban (TCC)
For each chemical, I will provide:For each chemical, I will provide:
 –
General environmental fate characteristicsGeneral environmental fate characteristics
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Representative environmental concentration dataRepresentative environmental concentration data
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Toxicity levels of most sensitive speciesToxicity levels of most sensitive species
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Comparison of concentrations and toxicity levelsComparison of concentrations and toxicity levels
 
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General EnvironmentalGeneral EnvironmentalFate PropertiesFate Properties
Both compounds have similar fate properties:Both compounds have similar fate properties:
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Very low vapor pressuresVery low vapor pressures
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Soluble in water Soluble in water 
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Highly adsorbent to organic matter Highly adsorbent to organic matter 
Both compounds will reach the environmentBoth compounds will reach the environmentthrough down-the-drain disposalthrough down-the-drain disposal
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Both show significant degradation in water treatment plantsBoth show significant degradation in water treatment plants(next slide)(next slide)
TCS shows rapid removal from water column in die-TCS shows rapid removal from water column in die-away studies (2-5 hour half-life)away studies (2-5 hour half-life)
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Also, biodegrades in soil in 17-35 daysAlso, biodegrades in soil in 17-35 days
TCC shows rapid degradation in biosolids (10 hour TCC shows rapid degradation in biosolids (10 hour half-life)half-life)

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