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HISTOLOGI
SISTEM REPRODUKSI LAKI-LAKI
Ika Fidianingsih
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Mengetahui tentang struktur histologi :
TESTIS
Tahap perkembangan sperma
SALURAN KELUAR GENITALIA
Tubuli rekti - duktus ejakulatorius
KELENJAR GENITALIA
Vesikula seminalis, prosta bulbouretralis
PENIS



TUJUAN
The Male Reproductive System
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The Male Reproductive System in
Anterior View
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1. Kulit
2. Muskulus dartos
3. Fascia skrotal superfisial
4. Musculus Kremaster
5. Lapisan parietalis Tunika vaginalis
merupakan membran serosa berasal dari peritoneum
6. Cavitas Scrotal
7. Pars viseralis Tunika vaginalis
8. Tunika Albuginea
Merupakan jaringan ikat fibrosa
Dibagian posterior tebal (mediatinum testis) -> septa
jaringan ikat membagi menjadi 250 lobuli testis
9. Tunika vaskulosa (jaringan ikat longgar dengan banyak
pembuluh darah)


PEMBUNGKUS TESTIS
The Structure of the Testes
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The tunica albuginea.
The visceral layer of the tunica vaginalis testis.
The large blood vessel, and inside of that the Tunica
Vasculosa.
Connective tissue septae from the Tunica Vasculosa
separate the seminiferous tubules from one another.

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Dipisahkan oleh septa jaringan ikat
Ada1- 4 tubulus seminiferus
Diantara tubulus seminiferus ada
Jaringan ikat longgar
Pembuluh darah
Pembuluh limfe
Saraf
Sel intertisial leydig


Tubulus semineferus - tubuli rekti - rete testis duktuli
efferen - duktus epididimis duktus deferen uktus
ejakulasios



LOBULI TESTIS
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Fig. Epithelium of
seminiferous tubules
surrounded by myoid
cells.

- The spaces between
the tubules :
- connective tissue,
- blood and lymphatic
vessels, and
- interstitial cells.

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Chapter 21 of Gartner and Hiatt: Color Textbook of
Histology, 3rd ed. Philadelphia, W.B. Saunders, 2007.


Leydig Cells

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Lamina basalis
Sel Sertoli
Sel epitel
germanativum
/spermatogonium
Spermatosit primer
Spermatosit
sekunder
Spermatid
Spermatozoa

Seminiferous Tubule

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Sel Sertoli
Sel ukuran besar, dengan inti besar
Mempunyai reseptor terhadap FSH
Menyokong & melindungi sel spermatogenik
Memfagosit sisa sitoplasma sprematid
Mensekresi fruktosa untuk nutrisi
Mensintesis Androgen binding protein >
mempertahankan kadar testosteron untuk
spermatogenesis
Mensisntesis Inhibin menghambat pelepasan FSH
Mensisntesis hormon antiimullerian menentukan seks
pria
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zonula occluden
/taut kedap)
antar sel sertoli >
ruang basal &
ruang adluminal
Melindungi sel
sperma dari
reaksi autoimun

Sel Sertoli menentukan sawar darah testis

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SPERMATOGENESIS
Spermatogonia (diploid) > bermitosis aktif
(mulai saat pubertas) > diferensiasi
spermatosit primer
Spermatosit primer > meiosis I
Spematosit sekunder > meiosis II
SPERMIOGENESIS
Spermatid (haploid) > diferensiasi
spermatozoa
Waktu sampai terbentuk spermatozoa, antara
tubulus seminiferus tidak sama
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Spermatozoa
Haploid : 22 + Y atau 22 + X
Motil setelah setelah keluar dari epididimis
Kepala mengandung Enzim hidrolitik
(membantu menembus corona radiata dan
zona pelusida oosit)


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Spermatocytus primarius, inti dengan
gambaran meiosis
Spermatocytus secundarius, sel lebih kecil,
terdapat lebih ke arah lumen
Spermatidium, sel memanjang dengan inti
ovoid
Spermatozoon :
di dlm testis , caput terpancang pd
epitheliocytus sustentans (dulu dsbt sel
Sertoli) inti berbentuk spt piramid
pada epididymis terdapat di dlm lumen
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Sistem saluran
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- pseudostratified
columnar epithelium
consisting primarily
of tall principal cells
(getting shorter
distally) with
stereocilia (getting
shorter distally) and
basal cells.
Terdapat otot polos Semakin ke duktus deferens,
epitel dan stereosilia menjadi semakin pendek, tetapi
otot menjadi semakin tebal
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-mucosa, :pseudostratified columnar epithelium.
-lamina propria.
-smooth muscle layers


Ductus deferens
Testes produce mature spermatozoa
Sperm enter epididymus
Elongated tubule with head, body and tail regions
Monitors and adjusts fluid in seminiferous tubules
Stores and protects spermatozoa
Facilitates functional maturation of spermatozoa
Male reproductive tract
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Seminal vesicles
Active secretory gland
Contributes ~60% total volume of semen
Secretions contain fructose, prostaglandins,
fibrinogen
Prostate gland
Secretes slightly acidic prostate fluid
Bulbourethral glands
Secrete alkaline mucus with lubricating properties
ejaculate = 2-5 ml fluid Contains between 20
100 million spermatozoa per ml


Accessory glands
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Accessory Glands
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Figure 2217. Seminal vesicle. A section of this tortuous tubular gland with a much-folded mucosa
gives the impression that the gland consists of many tubules. PSH stain. Medium magnification.
Seminal vesicle
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Prostate

-- Kelenjar paling besar
-Diantara uretra
-Kapsula kaya pembuluh
darah
-Sel-sel epitel dg jaringan
ikat padat ireguler & otot
polos
-Ada 30-50 tubuloalveolar
-Lumen : corpora
amylcea/prostatic concretio
(meningkat seiring umur)
--lipid, ez proteolitik, as
pospat, fibrinolisisn, as sitrat


Figure 2118 Human prostate gland.
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Figure 2218. Section of prostate showing the
distribution of its glands in 3 zones. The gland
ducts open into the urethra.
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Figure 2219. Section of the central region of the
prostate showing the prostatic urethra and
tubuloalveolar glands surrounded by connective tissue
and smooth muscle. PT stain. Low magnification.
Figure .Glands of the prostate
surrounded by connective tissue and
smooth muscle. PT stain. Medium
magnification.
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PENIS
Tunika Albuginea : jaringan ikat fibrosa
Corpora kavernosa
Ruang vaskuler banyak, tidak beraturan, dibatasi
sel endotel
Diantaranya jaringan ikat dan otot pols
Corpora spongiosa
Ruang vaskuler lebih seragam
Serabut elastin lebih banyak
Kelenjar Littre : lendir untuk uretra penis
Uretra

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1. Pars prostatica:
2. Pars membranacea
3. Pars spongiosa/cavernosa
Struktur :
Epitheliumtransitionale,pseudostratificatum
bagian yang terbesar
Lamina propria jar. ikat fibroelastik
Tunicamuscularis:
Stratum longitudinale
Stratum circulare
Urethra
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SOAL
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What is the function of the extremely thick
muscular coat in ductus defferen?
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