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CNS DRUGS 1 SEDATIVE HYPNOTICS

CNS DRUGS 1 SEDATIVE HYPNOTICS

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Published by: api-19641337 on Nov 28, 2009
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03/18/2014

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Pharmacology of CNS
Drugs
Pharmacology
Pharmacolo
\ue000Pharmacology
Pharmacology (from Greek,
(from Greek,p harmakon
pharmakon, "drug"; and
, "drug"; and\u2013
\u2013
logia, science
logia, science) is the study of drug action
) is the study of drug action
\ue000More specifically it is the study of the interactions that
More specifically it is the study of the interactions that
occur between a living organism and exogenous chemicals
occur between a living organism and exogenous chemicals
that alter normal biochemical function
that alter normal biochemical function
\ue000The field encompasses drug composition and properties,
The field encompasses drug composition and properties,
interactions, toxicology, therapy, and medical applications
interactions, toxicology, therapy, and medical applications
and antipathogenic capabilities.
and antipathogenic capabilities.
\ue000Pharmacology is not synonymous with pharmacy,
Pharmacology is not synonymous with pharmacy,
Pharmacology deals with how drugs interact within
Pharmacology deals with how drugs interact within
biological systems to affect function. It is the study of
biological systems to affect function. It is the study of
drugs, of the body's reaction to drugs, the sources of drugs,
drugs, of the body's reaction to drugs, the sources of drugs,
their nature, and their properties. In contrast, pharmacy is a
their nature, and their properties. In contrast, pharmacy is a
medical science concerned with the safe and effective use
medical science concerned with the safe and effective use
of medicines
of medicines
gy
Ion Channels & Neurotransmitter
Receptors
\ue000Neuronal excitability depends on the flux of ions
through specific channels in neuronal membranes
\ue000\u2191Na influx or \u2193K efflux \u2192excitation via membrane
depolarization.
\ue000\u2191Cl influx or \u2191K efflux \u2192 inhibition via membrane
hyperpolarization.
\ue000The membranes of nerve cells contain two types of
channels defined on the basis of the mechanisms
controlling their gating (opening and closing):
\ue000Voltage-gated
\ue000Ligand-gatedchannels

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