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EFFECT OF PHYSICO-CHEMICAL PROPERTIES OF DRUG ON ABSORPTION.ppt

EFFECT OF PHYSICO-CHEMICAL PROPERTIES OF DRUG ON ABSORPTION.ppt

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Published by noamalia

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Published by: noamalia on Jul 05, 2014
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July 5, 20141
EFFECT OF PHYSICO-CHEMICAL PROPERTIES OF DRUG ON ABSORPTION
 
July 5, 20142
Effect of drug dio!utio"
Factors affecting rate of release/dissolution and hence, bioavailability from solid dosage forms:
The rate and etent at !hich the drug in solution reaches the site "s# of absor$tion in absorbable form
The rate and etent of absor$tion across the gastro%intestinal barrier 
The etent to !hich the drug is metaboli&ed during $assage through the g'i't' and/or liver'
 
July 5, 2014(
)chematic re$resentation of dissolution of a drug $article in the g'i' fluid
Tablet*isintegration*e%aggregation+ranulesFine $articles*rug in solution *))-.T-
EXO-DISINTEGRANTENDODISINTEGRANT 

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