July 5, 20142
Effect of drug dio!utio"
Factors affecting rate of release/dissolution and hence, bioavailability from solid dosage forms:
The rate and etent at !hich the drug in solution reaches the site "s# of absor$tion in absorbable form
The rate and etent of absor$tion across the gastro%intestinal barrier
The etent to !hich the drug is metaboli&ed during $assage through the g'i't' and/or liver'