Journal of Comparative Pathology 2008-2009Feline
Arteriovenous Haemangioma in Two Dogs and a Cat-
These are rare tumors withdifferentiation into arterioles, venules and capillaries. All haveVWF + endothelium and Smooth muscleActin+ tunica media.
Malakoplakia in the Urinary Bladder of a Kitten
-- Malakoplakia is a form of chronicgranulomatousinflammation that in humans most commonly affects the urinary bladder of middle-aged women, it is rare in animals. Gross lesions included a markedly enlarged bladder with adiffusely nodular mucosal surface. Microscopically, there was diffusesubmucosal infiltration byhistiocytes stained positively by periodic acid Schiff (PAS)and described in the human condition as ‘‘von Hansemann cells’’. Intracellular andextracellular ‘‘Michaelise Gutman’’ inclusion bodies were seen on light and electronmicroscopical examination. These structures are considered pathognomonic for malakoplakia.
Bone Marrow Pathology in Dogs and Cats with Non-Regenerative Immune-Mediated Haemolytic Anaemia and Pure Red Cell Aplasia: N
on-regenerative IMHAin dogs and cats has been associated with pure red cell aplasia, erythroid maturationarrest or bone marrow erythroid hyperplasia. PRCA and erythroid maturation arrest mayresult from immune-mediated destruction of erythroid precursor cells within the bonemarrow. However, IMHA due to erythroid hyperplasia could be due to variety of pathological changes in bone marrow including dysmyelopoiesis, myelonecrosis,myelofibrosis, altered vascular permeability/acute inflammation, and hemophagocyticsyndrome
Spinal Cryptococcoma in an Immunocompetent Cat (
J. Comp. Path. 2008, Vol. 139, 246e251
Focal Malacia in the spinal cord.
The yeasts wereround in shape, 7 mm in diameter and rimmed by a basophilic thin cell wall, which wassurrounded by a halo of variable thickness. Narrow-necked budding forms were also present. The parenchymal remnants contained digestion chambers in which Gitter cells,spheroids and myelinic debris were present.
Multiple hepatic vascular cysts in a young ragdoll cat
: In cats and dogs, the DDx for congenital intrahepatic cystic structures would include a biliary cyst or pseudocyst,choledochal cysts or cystic duct remnants. For acquired cysts or other cavitatedstructures, abscesses, parasitic cysts, biliary cyst adenoma, cystadenocarcinoma,cholangiocarcinoma, haemangiosarcoma, and certain metastatic tumours
An Immunohistochemical Study of Feline Endometrial Adenocarcinoma
J. Comp. Path. 2009, Vol. -, 1e6
. Feline endometrial adenocarcinomas are uncommon. Normalendometria and Neoplastic lesions express pancytokeratins AE1 and AE3, cytokeratin-14, vimentin, a-actin, cyclo-oxygenase-2, E-cadherin, b-catenin, the progesteronereceptor, the estrogen receptor and caveolin-1. Synthesis of cyclo-oxygenase-2 andreduced expression of progesterone receptors may be involved in the neoplastictransformation of feline endometrium. The loss of cellular adhesion that occurs within