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Feline Journal Summaries

Feline Journal Summaries

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Published by vetpathforum
Journal of Comparative Pathology 2008-2009 Feline Arteriovenous Haemangioma in Two Dogs and a Cat- These are rare tumors with
differentiation into arterioles, venules and capillaries. All have VWF + endothelium and Smooth muscle Actin + tunica media.

Malakoplakia in the Urinary Bladder of a Kitten -- Malakoplakia is a form of chronic granulomatous inflammation that in humans most commonly affects the urinary bladder of middle-aged women, it is rare in animals. Gross lesions included a markedly
Journal of Comparative Pathology 2008-2009 Feline Arteriovenous Haemangioma in Two Dogs and a Cat- These are rare tumors with
differentiation into arterioles, venules and capillaries. All have VWF + endothelium and Smooth muscle Actin + tunica media.

Malakoplakia in the Urinary Bladder of a Kitten -- Malakoplakia is a form of chronic granulomatous inflammation that in humans most commonly affects the urinary bladder of middle-aged women, it is rare in animals. Gross lesions included a markedly

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Published by: vetpathforum on Dec 01, 2009
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Journal of Comparative Pathology 2008-2009Feline
Arteriovenous Haemangioma in Two Dogs and a Cat-
These are rare tumors withdifferentiation into arterioles, venules and capillaries. All haveVWF + endothelium and Smooth muscleActin+ tunica media.
Malakoplakia in the Urinary Bladder of a Kitten
-- Malakoplakia is a form of chronicgranulomatousinflammation that in humans most commonly affects the urinary bladder of middle-aged women, it is rare in animals. Gross lesions included a markedly enlarged bladder with adiffusely nodular mucosal surface. Microscopically, there was diffusesubmucosal infiltration byhistiocytes stained positively by periodic acid Schiff (PAS)and described in the human condition as ‘‘von Hansemann cells’’. Intracellular andextracellular ‘‘Michaelise Gutman’’ inclusion bodies were seen on light and electronmicroscopical examination. These structures are considered pathognomonic for malakoplakia.
Bone Marrow Pathology in Dogs and Cats with Non-Regenerative Immune-Mediated Haemolytic Anaemia and Pure Red Cell Aplasia: N
on-regenerative IMHAin dogs and cats has been associated with pure red cell aplasia, erythroid maturationarrest or bone marrow erythroid hyperplasia. PRCA and erythroid maturation arrest mayresult from immune-mediated destruction of erythroid precursor cells within the bonemarrow. However, IMHA due to erythroid hyperplasia could be due to variety of  pathological changes in bone marrow including dysmyelopoiesis, myelonecrosis,myelofibrosis, altered vascular permeability/acute inflammation, and hemophagocyticsyndrome
Spinal Cryptococcoma in an Immunocompetent Cat (
J. Comp. Path. 2008, Vol. 139, 246e251
).Gross lesion:
Focal Malacia in the spinal cord.
Microscopic lesion:
The yeasts wereround in shape, 7 mm in diameter and rimmed by a basophilic thin cell wall, which wassurrounded by a halo of variable thickness. Narrow-necked budding forms were also present. The parenchymal remnants contained digestion chambers in which Gitter cells,spheroids and myelinic debris were present.
Multiple hepatic vascular cysts in a young ragdoll cat
: In cats and dogs, the DDx for congenital intrahepatic cystic structures would include a biliary cyst or pseudocyst,choledochal cysts or cystic duct remnants. For acquired cysts or other cavitatedstructures, abscesses, parasitic cysts, biliary cyst adenoma, cystadenocarcinoma,cholangiocarcinoma, haemangiosarcoma, and certain metastatic tumours
An Immunohistochemical Study of Feline Endometrial Adenocarcinoma
.
 J. Comp. Path. 2009, Vol. -, 1e6 
. Feline endometrial adenocarcinomas are uncommon. Normalendometria and Neoplastic lesions express pancytokeratins AE1 and AE3, cytokeratin-14, vimentin, a-actin, cyclo-oxygenase-2, E-cadherin, b-catenin, the progesteronereceptor, the estrogen receptor and caveolin-1. Synthesis of cyclo-oxygenase-2 andreduced expression of progesterone receptors may be involved in the neoplastictransformation of feline endometrium. The loss of cellular adhesion that occurs within
 
these tumours does
not
require down-regulation of E-cadherin expression and nuclear translocation of b-catenin is
not
a feature of these neoplasms.
Muscular Dystrophy with Reduced β-Sarcoglycan in a Cat
.
 J. Comp. Path. 2009,Vol. -, 1e5
. Sarcoglycans (SGs) are sarcolemmal transmembrane glycoproteins that forma hetero- tetrameric complex known as the sarcoglycan complex (SGC). The SGC is amember of the dystrophin glycoprotein complex, which links actin in the cytoskeleton tothe extracellular matrix through α2-laminin, providing protection of the sarcolemma fromtension during muscle contraction. SGC also has a role in intracellular signaltransduction. Muscle biopsy revealed moderate variability in myofiber size, withnumerous
atrophic rounded fibers
, rare myofiber necrosis,
regeneration
and moderate
perimysial andendomysial fibrosis
. Immunohistochemistry revealed
decreasedexpression of β- and γ-SG
and western blotting revealed markedly decreased β-SG withnormal expression of α-, γ- and δ-SG, caveolin-3 and calpain-3. Not previously known incats.
Detection of mixed infections with ‘‘Candidatus Mycoplasmahaemominutum’’ and Mycoplasma haemofelis using real-timeTaqMan polymerase chain reaction
. J Vet Diagn Invest 19:250–255(2007).Hemotropic mycoplasmas (hemoplasmas) are epierythrocyticmycoplasmas that have never been cultured in vitro. At least 3 speciesinfect cats: Mycoplasma haemofelis (Mhf) and ‘Candidatus Mycoplasmahaemominutum’ (Mhm), as well as ‘Candidatus Mycoplasma turicensis’(Mtc), a new species that was recently described in cats in Switzerland. The latter species appears to be present in cats in North America, aswell as an organism related to ‘Candidatus M. haematoparvum’ (Mhp),which was first identified in dogs. Mhf is capable of causing severeanemia in cats, whereas Mhm has yet to be associated with disease inimmunocompetent cats.
Light-chain multiple myeloma in a cat.
J Vet Diagn Invest 19:443–447 (2007). IN general, the monoclonal immunoglobulin produced inmultiple myeloma may be an entire immunoglobulin of any class, aheavy chain only, or a light chain only (light-chain multiple myeloma,also called Bence-Jones myeloma). In this case, the cat had atypicalplasma cell infiltration in the bone marrow, biclonal gammopathycaused by polymerization of myeloma protein (M-protein), and Bence- Jones proteinuria.
Sinonasal plasmacytoma in a cat
. J Vet Diagn Invest 19:573–577(2007). The right nasal cavity and the right frontal sinus were partiallyoccluded by a soft whitish mass. Microscopically, the mass wascomposed of well-differentiated plasma cells that wereimmunopositive forimmunoglobulin G and lambda light chains. Thesefindings were consistent with a mature type sinonasal plasmacytoma.
 
Nocardia tenerifensisgenome identification in a cutaneousgranuloma of a cat.
J Vet Diagn Invest 19:577–580 (2007).subcutaneous mass in its tail. Histologically, this mass consisted of ill-definedpyogranulomas centered around aggregates of gram-positive,acid-fast filamentous bacteria, consistent with Nocardia.
Assessment of melamine and cyanuric acidtoxicity in cats.
JVet Diagn Invest 19:616–624 (2007). Urine and touch impressions of kidneys from all cats dosed with the combination revealed thepresence of fan-shaped, birefringent crystals. Histopathologic findingswere limited to the kidneys and included crystals primarily withintubules of the distal nephron, severe renal interstitial edema, andhemorrhage at the corticomedullary junction. The kidneys containedestimated melamine concentrations of 496 to 734 mg/kg wet weightand estimated cyanuric acid concentrations of 487 to 690 mg/kg wetweight. The results demonstrate that the combination of melamine andcyanuric acid is responsible for acute renal failure in cats.
Immunohistochemical characterization of ahepatic neuroendocrine carcinomain acat. J Vet Diagn Invest 20:110–114 (2008).
yellow-brown, firm, multilobulated tumor was identified in the liver. Microscopically, the mass consisted of neoplastic cellsarranged in small, closely packed nests within a thin fibrovascular stroma.Immunohistochemically, most of the neoplastic cells were immunoreactive for chromogranin A, neuronspecific enolase (NSE), and cytokeratin AE1/AE3 and weaklylabeled for synaptophysin.The tumor was negative for glial fibrillary acidic protein(GFAP), vimentin, and cytokeratins. These tumors initially described in the smallintestine of human beings were first named carcinoid. The term neuroendocrinecarcinoma is now used for all neuroendocrine tumors, acknowledging that allneuroendocrine tumors are potentially malignant.
A case of coccygeal chondroid chordoma in a cat: morphological andimmunohistochemical features. J Vet Diagn Invest 20:679–681 (2008).
mass on thetip of the tail. Histological examination performed after apical caudectomy revealed aneoplasm affectingthe distal part of the last coccygeal vertebra. The neoplasm consisted of lobulesof  physaliferous cells surrounding cartilaginous tissue and a central core of trabecular bone.
Perforin expression in feline epitheliotropic cutaneous lymphoma. J Vet DiagnInvest 20:831–835 (2008).
Granular lymphocyteswere consistently detected on bloodsmears, and histologically, the tumor involved the skin and superficial subcutis. Tumor lymphocytes expressed cluster of differentiation 3(CD3)and perforin molecules, suggestive of a cytotoxic phenotype. Location, histopathological features, and perforinexpression were similar to a distinct entity in human medicine designated primarycutaneous,CD8-positive, epidermotropic, cytotoxic, T-cell lymphoma.

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