Augmentin, Clavamox, TyclavAmoclav
Dosage & Route
Oral (Children) < 1 yr 2.5 mL (1/2 tsp) of
228.5 mg/5 mL
1 to 6 yrs 2.5 mL (1/2 tsp) of 457 mg/5 mL
6 to 12 yrs10 to 20 mL (2 to 4 tsp) of 228.5 mg/5 mL
Mechanism of Action
Clavulanic acid has negligible intrinsic antimicrobial activity,
despite sharing the β
-lactam ring that is characteristic of
-lactam antibiotics. However, the similarity in chemical structure allows the molecule to interact with the enzyme
-lactamase secreted by certain bacteria to confer resistance t
of the β
-lactamase. This restructures the clavulanic acid molecule, creating a much more reactive species that is attacked by another amino acid in the active site, permanently inactivating it, and thus inactivating the enzyme.
This inhibition restores the antimicrobial activity of β
-lactam antibiotics against lactamase-secreting resistant bacteria. Despite this, some bacterial strains that are resistant even to such combinations have emerged.
Hepatitis, Cholestatic jaundice, Erythema multiforme (including Stevens-Johnson syndrome), Toxic epidermal necrolysis, Exfoliative dermatitis, Vasculitis, Dizziness, Headache, Convulsions (especially in high doses or in renal impairment), Superficial teeth staining when using the suspension.
Assess bowel pattern before and during treatment as pseudomembranous colitis may occur.
Report haematuria or oliguria as high doses can be nephrotoxic.
Assess respiratory status.
Observe for anaphylaxis.
Ensure that the patient has adequate fluid intake during any diarrhoea attack.