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chapter 21 lipid biosynthesis

chapter 21 lipid biosynthesis

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Published by: api-19916399 on Dec 02, 2009
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03/18/2014

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Chapter 22
Chapter 22
Lipid Biosynthesis
Lipid Biosynthesis
Biosynthesis of fatty
acid
1.
1.Fatty acid synthesis takes a different
Fatty acid synthesis takes a different
pathway from its degradation
pathway from its degradation
\ue000Occurs in the cytosol
\ue000Acetyl-CoA provides the first two carbons, which is elongated
by sequential addition of two-carbon units donated from
malonyl-CoA.
\ue000Intermediates are attached to the -SH groups of an acyl carrier
protein (ACP).
\ue000NADPH is the reductant.
\ue000The enzymes are associated as a multi-enzyme complex or
even being in one polypeptide chain in higher organisms (fatty
acid synthase).
\ue000Elongation by the fatty acid synthase
complex stops upon formation ofpalmitate
(C16), further elongation and desaturation are
carried out by other enzyme systems.

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