Istorie a utilizarii aluminiului

In cazul adjuvantilor din vaccinuri

Aluminum salts are the most widely used adjuvants for human vaccines.
1926 - Glenny et al were the first researchers to demonstrate the adjuvant effect of aluminum
compounds*
1932 Aluminum salt found to enhance diphtheria toxoid immunization in humans
1934 Immunization of guinea pigs with aluminum salt and pollen extracts was found to
increase allergic sensitization
1938 Sledge et al demonstrated that aluminum hydroxide-adsorbed allergen extracts
improved stimulatory as well as reduced anaphylactic properties