Dr Alan Calderon Villarreal R2GO

HGZ UMF 16 Torreon

Recomendacion
Metanalisis de Chochrane
6145 recin nacidos:
Tratamiento con Sulfato de Mg antenatal como
terapia en mujeres con riesgo de parto
pretermino
Reduccin de riesgo de parlisis cerebral -Relative Risk
(RR) 0.68; 95% (IC) 0.54 to 0.87
Reduccin de disfuncin motora RR 0.61; 95% CI 0.44 to
0.85;

Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus (Review)
Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons,

Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus (Review)
Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons,
Kuban and colleagues in 1992
Reduccion de Hemorragia intraventricular del 18.9% al
4.4% en prematuros menores de 1500gr
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus (Review)
Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons,
Exitotoxinas, lesion neurnal,
hipoxia,
Las excitotoxinas como el
NMDA y el cido kanico
Altos niveles patolgicos de
glutamato, pueden
provocar la excitotoxicidad
Niveles elevados de iones
de calcio entren en
la clula.
La entrada de Ca++ en las
clulas activafosfolipasas,
endonucleasas,
Poteasas (calpalina).
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus (Review)
Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons,
Estudios en animales demostraron el efecto del sulfato
de Mg al bloquear el exeso de glutamato en efeto
directo sobre receptores de Ca y de glutamato.
Magnesium sulphate for women at risk of preterm birth for neuroprotection of the fetus (Review)
Copyright 2009 The Cochrane Collaboration. Published by John Wiley & Sons,