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The natural cycle of sleep and wakefulness is regulated by the nervous system.
Suprachiasmatic nucleus
is a structure in the hypothalamus which is specifically involved in theregulation of circadian rhythms (brain wave rhythms, hormone production, cell regeneration,etc). The hypothalamus secretes various hormones which influence the sleep and wake state of mind. These are various neurohormones and neurotransmitters which are linked with andencourage sleep like melatonin, which promotes sleep, and adenosine, which accumulates duringwakefulness, encouraging sleep, and then decreases during sleep. Other areas of the brain such asmedulla and thalamus also control sleep and arousal.Benington, Kodali and Heller (1995) suggested that a nucleoside neurotransmitter,
adenosine
, could be one of the primary controlling agents of sleep.
G
lucose is supplied by bloodto the brain when cognitive activities take place. But when blood fails to provide the requiredamount of glucose due to high activity of the brain, Astrocytes provide the needed nutrition inform of glycogen. The increase in the level of the metabolism of glycogen increases the levels of adenosine. This increase of adenosine increases the amount of delta activity during sleep. Recentresearches also verify the hypothesis of adenosine as a mechanism which regulates sleep.
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Very useful.. Thanks!