Diseases related with

uveitis
JUVENILE RHEUMATOID ARTHRITIS
Penyakit peradangan sendi perifer kronik
yang timbul pada usia dibawah 16 tahun :
rheumatoid factor negatif

3 tipe : sistemik ( penyakit Still) , poliartikular,
pausiartikular

Reaksi autoimun yang bersifat sistemik
JRA
Tipe sistemik : demam, mialgia, limfadenopati,
hepatosplenomegali & radang sendi perifer

Tipe Poliartikular : peradangan 5 sendi / lebih
(bentuk paling sering)

Tipe Pausiartikular : peradangan 4 sendi / lebih


Kel. HLA B27 & Kel. ANA (Antinuclear antibody)

Juvenile rheumatoid arthritis
Pauciarticular Polyarticular Systemic
(60%) (20%) (20%)
< 5 > 4 Variable
< 6 years Variable Variable
Absent Mild or absent Severe
Joints no.
Onset
Systemic features
Positive ANA
Iridocyclitis
20% 5% Absent
75% 40% 10%
Diagnosis
Anamnesis
Tanda klinis khas uveitis
Pemeriksaan penunjang : ANA (+) ; RF (-) ;
HLA B 27 (+)

BEHCET S DISEASE
Penyakit inflamasi sistemik dan kronik
berulang yang ditandai dengan trias : aphtae
orogenital, inflamasi okular & lesi kulit

Gangguan SSP , ulkus gastrointestinal

HLA B 51
FINDING DEFINITION
Recurrent oral ulceration Minor aphthous, major aphthous, or herpetiform ulcers
which have recurred at least three times over 12 month period

Plus two of :


Recurrent genital ulceration Aphthous ulceration or scarring


Eye lesions Anterior uveitis, posterior uveitis, or cells in the vitreous
; or retinal vasculitis


Skin lesions Erythema nodosum observed by the physician or patient
, pseudofolliculitis, or papulopustular lessions
; or acneiform nodules


Positive pathergy test Test interpreted as positive by the physician at 24 to 48 hours

International Study Group for Behcets Disease
Uveitis in Behet disease
Acute iritis Retinitis
Diffuse leakage
Vaskulitis
Diagnosis
Anamnesis
Tanda klinis ISG for Behcet disease
Tanda klinis khas uveitis
Pemeriksaan penunjang : HLA B 51 (+)

Vogt Koyanagi Harada Syndrom
(VKH)
Penyakit inflamasi, idiopatik autoimun
ditandai dengan panuveitis granulomatosa
bilateral serta manifestasi ekstraokular pada
SSP, sistim pendengaran dan integumentari


VKH
Fase prodromal : sakit kepala hebat, kaku kuduk,
tinitus, eritema kulit & scalp tenderness

Fase uveitis akut : penglihatan buram ; kelainan mata
related uveitis

Fase Kronik : Sugiura sign ( depigmentasi limbus) ;
Sunset glow ( hilangnya melanosit koroid) ; pigment
clumps ; Nodul Dalen-Fuchs ( lesi hipopigmentasi)

Fase rekuren : panuveitis + komplikasi
Kelainan integumenter : poliosis, vitiligo, alopecia
Neurologis : meningismus ; tinnitus
Signs of Vogt-Koyanagi syndrome
Granulomatous
iridocyclitis
Alopecia
Poliosis Vitiligo
Harada syndrome
Multifocal sensory retinal
detachments
Multifocal choroiditis
Exudative retinal
detachment
Progression of Harada disease
Diagnosis
Anamnesis
Tanda klinis khas uveitis
Pemeriksaan penunjang :
Pungsi lumbal : pleositosis di cairan cerebrospinal
USG : kekeruhan vitreus ; ablasio retina