15.05.

2014

2014

80%
20%
. 1%
(, ).

,
.

,
,
,
( - ).

, .

.... .

1.
() RNA Flavivirus
Flaviviridae. .

(lineages):
lineage 1 , ,

.
lineage 2 2004 ,
, , ,
, (2004, 2005-2009, ), (2007,
) (2008-2009, ),
(2010-2013)

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 15.05.2014

2.

. Culex ( )
Culex pipiens.
( ),
.
(reservoir) .
( ) , () ,

.
,
-, .
,
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, .

. -


.
3.

1937 ,
. , 1950,
, 1951 ,

1957. , 1960 , ,
, , ,
, , , , , 15-20
. .
, , ,
.
.
: 1960
,
1990 . , /
- .
1996-1997,
1999 . 2010
.
,
1996
.
1999 , ,
,
.

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 15.05.2014

2010 , - -
, . 2010
. ,
( 1980, 2007) 1%
.
2011 . 2012
, ( )
( ,
), 2013 , , ,
( )
. , ,
, .

. 2010
, WNV-lineage 2, , Nea Santa-Greece-2010,
, .
,
, 2010 - 2013.
: ,
(), , 2010 - 2013

2010

2011

2012

2013

262

100

161

86

197

75

109

51

65

25

52

35

1,8/100.000

0,7/100.000

1,0/100.000

0,5/100.000

33

18

10

17%

12%

17%

20%

*


*

.. ( 2011).

....
....
( , 2010, 2011, 2012, 2013).

:
: , ,
, . - ( - ).
, , .
, ,
1999 ( ),
>300 .
: , ,
. .
( 10%) ,

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 15.05.2014

.
38-57%.
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. , ,
.
(, , , ..),

.
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.
, ,
.

.

, , , :
.
.
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)
( ).
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.
(,
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).
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.
5.

2 14 ,
( ) .
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.
75-80%.
(West Nile fever):
20-25% ,

- , :
- ( ).
- .
.
- , .
- , , , .



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 15.05.2014

- , , ,
, (
).
- ( ).
- ( ).
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- (West Nile neuro-invasive disease):

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- , (),
, -,
.
2010,

140 ( ).
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- .
- .
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.

, , (, ,
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, ,
, .

-,
.
4/5
. ,
, (
48), ,
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, .
.
, .
.



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 15.05.2014

, ,
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.
( , ,
) .

:
, ( ,
, , , ,
).
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, .

.
, - 27

.
.
, 2010 - 2013
, 2010 2013 609
, 432 (- ).
432 - , 83% (n=357)
, 15% (n=64) , 24 (6%)
( 11 13
).
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, 12% 20%.
- 72 (: 2-95 ) 60%
. 88% 50
60% 70 .
- : ( 96%
), (61%), / (59%), /
(44%), (, , ) (30%),
(29%), (29%), / (26%), (18%), (18%),
(15%), (14%), (13%), (12%),
(11%), (5%).
77% - ,
(43%), (31%), (25%), (11%),
(8%), (7%).
11% (n=70) 16% (n=68) -
(). 47% (n=33)
- .
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-
( ),
3 6 ( ).
,
, , , ,
, , .
, ,
.

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 15.05.2014

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, ,
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, . ,
.
, 1/3
, 1/3
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15-29% >70 . 10%, , 2010-2013,
12-20%. -
().
RNA 7 ,

,
. ,
.
.
8.

, (>50 )
.
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), , .

, .
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.
:

, .
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,
,
- , ,
- .
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,
.



. 210-8899052, 210-8899072, www.keelpno.gr

 15.05.2014

,
/
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.
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,
. ,

.

, ,
:
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ii. ,
iii.
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iv. ,
.

, .

. ,
.
11.
:
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- - IgM
, / :
IgM : IgM
,
.
90% IgM
8 .
IgM : IgM 3
8 . IgM
,
-
. (..
) ,
. , IgM
,
IgM .
, ,
IgM :
-
.
- ,
.



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 15.05.2014

8 ,
IgM
.
IgG IgM
( ). ,
IgG . ,
IgG ,
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.
, PCR
. RNA

.

III.

Nucleic Acid mplification Testing (NAT)

.

IV.

( ): ,
. , .
.

12.

(, , )
, :
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,
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2)

, ,
(. . , . 210 746 2011, 210 746 2133, 210 746 2140)
: , , ,
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3) : , ,
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,

.....
13.
. ,

, , ,
.
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. (.. -2, , , , )
,

.



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 15.05.2014

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.
.
:
1. W. West Nile virus. Fact sheet (July 2011).
http://www.who.int/mediacentre/factsheets/fs354/en/
2. ECDC. West Nile fever. Factsheet for health professionals.
http://www.ecdc.europa.eu/en/healthtopics/west_nile_fever/factsheet-for-healthprofessionals/Pages/factsheet_health_professionals.aspx
3. ECDC TECHNICAL REPORT. West Nile virus risk assessment tool.
http://ecdc.europa.eu/en/publications/publications/west-nile-virus-risk-assessment-tool.pdf
4. CDC. West Nile Virus. Information for Health Care Providers.
http://www.cdc.gov/westnile/healthCareProviders/
5. Petersen LR1, Brault AC, Nasci RS. West Nile virus: review of the literature. JAMA. 2013 Jul
17;310(3):308-15.
6. Marka A, Diamantidis A, Papa A, Valiakos G, Chaintoutis SC, Doukas D, et al. West Nile virus state of
the art report of MALWEST Project. Int J Environ Res Public Health. 2013;10(12):6534-6610.



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