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Diagrams:

Diagram I
Pathogenesis of Insulin Dependent DM (Type 1)






















Genetic Predisposition (Susceptibility)


Environmental
insult
- Viral infection
- Toxic chemical
agents

Autoimmunity
-Lymphocyte
infiltration
-Insulitis
Immunologic Response
- Islet cell antibodies
- Cell- mediated immunity
cell destruction
Lack of insulin release
Insulin Dependent Diabetes Mellitus (IDDM)





Diagram II
Pathogenesis of Non- Insulin Dependent DM (Type 2)





















Hereditary
Factors
Obesity
Delayed or insufficient insulin
secretion
Insulin resistance (Receptor
defect or other events)
Increased insulin demand
cell exhaustion and dysfunction
Impaired secretion
of insulin
Hyperglycemia
Non- Insulin Dependent DM (NIDDM)

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