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Precipitating factors:
1.frequent or chronic infections2.eating too much sweets3.development of glucoseintolerance during drugtherapy4.delivery of over 9 lbs infants5.diet6.sedentary lifestyle
Predisposing factors:
1.family history of DM2.obesity3.Age above 40Exhaustion of beta cells
Absorption of glucose by the cellCell starvationDegradation of proteins
Breakdown of fat
Insulin production/decrease secretion of insulinStimulation of hunger mechanism via hypothalamusHunger Insulin resistance
Ideal Pathophysiology of Diabetes Mellitus Type II
 
FBS
140 mg/dLPOLYPHAGIAHYPERGLYCEMIAFBS
 
to 180 mg/dLKidney filtration mechanism impairedGLYCOSURIA
Acidity of urine
Urethral floraUTINerve DemyelinizationParesthesias &numbnessImpaired painsensation
Circulatingblood volumeDelayed woundhealingGangrenePOLYURIA &ALBUMINURIACapillary basementmembrane thickeningHypovolemia
HYPOTENSION &TACHYCARDIA
Diffuse glomerular sclerosisRenal failureVaginitisNEPHROPATHYNEUROPATHYNON-HEALINGULCERSEnd-Stage RenalDisease
 
Number of solute relative to water Sodium ions lostTissue dehydrationPotassium ion retentionCardiac arrythmiasF & E imbalancePOLYDIPSIACapillary basementmembrane thickeningAbnormal retinal vascular permeabilityScarringThickening of bloodvessel wallsOcclusion of plaqueBlood flow blocked
Blood pressureMusculoskeletal effectsImpaired glucose absorption inthe muscle tissueJoint contracturesIncrease viscosity of bloodblindnessBlurring of vision
 
BlindnessStrokeFATIGUEMyocardialinfarctionMyocardialischemiaDiminishedperipheralpulseHeart FailureDEATHRETINOPATHYHYPERTENSION
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01 / 13 / 2010This doucment made it onto the Rising List!
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