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pengaruh durasi menderita diabetes melitus terhadap derajat neuropati perifer berdasarkan DNS dan DNE

pengaruh durasi menderita diabetes melitus terhadap derajat neuropati perifer berdasarkan DNS dan DNE

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diabetes melitus,neuropati perifer,DNS,DNE
diabetes melitus,neuropati perifer,DNS,DNE

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Published by: Martini Aulya Syamsurijal on Dec 16, 2009
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02/17/2013

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INFLUENCE DURATION OF DIABETES MELLITUSTOWARD PERIPHERAL NEUROPATHY DEGREE(BASED ON DNS AND DNE)
Martini Aulya Syamsurijal
1
, Tri Wahyuliati
2
1.Student of Faculty of Medicine, Muhammadiyah University of Yogyakarta2.Neurology Department, Faculty of Medicine, Muhammadiyah University of YogyakartaFakultas Kedokteran Universitas Muhammadiyah YogyakartaJl. Lingkar Barat, Tamantirto, Kasihan, BantulYogyakarta
ABSTRACT
 
 
 Diabetes
mellitus is becoming one of the most important health
 
 problems not onlyin developed countries but also in developin
 
countries. Because of the highmorbidity and 
 
mortality associated with complications of 
diabetes
 ,
diabetes
mellitusis
 
a burden on both patients and society. Peripheral 
neuropathy
is common, oftendistressing, and sometimes disabling or even fatal. Objectives of this study is to knowinfluence duration of diabetes mellitus toward peripheral neuropathy degree based on DNS (Diabetic Neuropathy Score) and DNE (Diabetic Neuropathy Examination).In this cross sectional study, 66 diabetic in-patients were selected from PKU Muhammadiyah hospital of Yogyakarta and Wates region public hospital. Studiesdata were got through observation and variable measuring. The course of the studieswere secondary data registration by reading patient document at hospital, direct interview with sample, anamnased and physical examination. After each variablewere collected, data were analyzed using Spearmen correlation, Chi Square test, and Odds Ratio (OR).Statistically significant relationship were found between neuropathy degree withduration of disease and cardiovascular history based on DNE. P value both of themwere <0,001. Cardiovascular disease, hypertension, hypertension history, and  smoking were risk factor for peripheral neuropathy degree with OR >1. Nocorrelation were found between neuropathy degree and hyperglycemia, dyslipidemia,dyslipidemia history, BMI, and type of DM. In conclusion, there are correlationbetween duration of DM with peripheral neuropathy degree. Keyword : diabetes mellitus duration, peripheral neuropathy degree, DNS, DNE 
INTISARI
2
 
Diabetes melitus (DM) merupakan salah satu masalah kesehatan terpenting tidak hanya di negara maju, tapi juga di negara yang sedang berkembang. Tingginya angkamorbiditas dan mortalitas yang dihubungkan dengan komplikasi DM menyebabkanDM menjadi beban bagi pasien dan juga sosial. Neuropati diabetik perifer adalahkomplikasi DM yang paling umum dan sering menyusahkan dan kadang-kadangmelumpuhkan atau bahkan menimbulkan kematian
.
Penelitian ini bertujuan untuk mengetahui pengaruh durasi menderita DM terhadap derajat neuropati perife berdasarkan skor DNS dan DNE.
 
Penelitian ini menggunakan metode penelitian
observasional 
 
analitik 
dengandesain
cross sectional 
 
 study.
Sampel penelitian meliputi penderita DM rawat inap diRS PKU Muhammadiyah Yogyakarta dan RSUD Wates Kulon Progo Yogyakartasebanyak 66 sampel. Data penelitian diperoleh melalui observasi dan pengukuranvariabel yang diawali pencatatan data sekunder dengan membaca status pasien dirumah sakit, selanjutnya wawancara langsung dengan sampel, anamnesis dan pemeriksaan fisik. Setelah data masing-masing variabel terkumpul, kemudiandilakukan uji statistik korelasi
 Pearson
, uji
Chi Square
dan
Odds Ratio
(OR).Hubungan yang signifikan dari uji statistik ditemukan diantara derajat neuropati perifer dengan variabel durasi menderita DM dan riwayat kardiovaskuler berdasarkanDNE dengan nilai p keduanya adalah <0,001. Variabel penyakit kardiovaskuler,hipertensi, riwayat hipertensi, dan merokok termasuk dalam faktor resiko yangsignifikan yang ditunjukkan nilai OR >1.
 
Tidak ditemukan hubungan antara derajatneuropati perifer dengan hiperglikemia, dislipidemia, riwayat dislipidemia, BMI, dantipe DM. Dari hasil penelitian ini dapat dibuktikan bahwa terdapat hubungan durasimenderita diabetes melitus terhadap derajat neuropati perifer.Kata kunci : durasi menderita DM, derajat neuropati perifer, DNS, DNE
PENDAHULUAN
3

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