Nephroblastoma "Wilms' tumour"
Wilms' tumor is a rare kidney cancer that primarily affects children. Also known asnephroblastoma, it's the most common malignant tumor of the kidneys in children.The peak time of Wilms' tumor occurrence is around ages 3 to 4, and it occurs onlyrarely after age 6.Although Wilms' tumor can occur in both kidneys, it tends to affect just one kidney.Wilms' tumor is believed to develop from immature kidney cells.Improved imaging techniques help doctors to determine the extent of the cancer inWilms' tumor and to plan treatment. The outlook for most children with Wilms' tumor is very good.
synchronous or metachronous bilateral involvement in 5–10%
Solitary ,well circumscribed ,rounded ,soft consistency
Size variable (median 550 g)
predominantly solid and pale gray or tan gray
often cystic change, necrosis, and hemorrhage
Three major components:
extremely cellular& small round-to-oval primitive cells
cytoplasm usually scanty& sometimes oncocytoid appearance