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Embryonal Tumours(3)

Embryonal Tumours(3)

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Published by Ahmad Yasser

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Published by: Ahmad Yasser on Jan 02, 2010
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05/18/2012

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Ain Shams UniversityFaculty of MedicinePathology Department2009/2010 
Embryonic tumors
Names:1- Ahmed Yaser 15202- Osama 15213- Eslam Mubarak Mohamed 15224- Asmaa Ahmed Mhmoud 1523
 
Definition of Embryonic tumors
This broad group of childhood tumours crosses over the standard classification, because embryonal tumoursThey are characterised by the proliferation of tissue that is normally seen only in thedeveloping embryo. They are generally very rare after childhood, and occur mostcommonly in the first few years of life. Several types of embryonal tumour have a peak of incidence in the first year of life. Some types are occasionally found to be present at birth.
They occur as:
1.Wilms’ tumour (nephroblastoma) in the kidney 2.retinoblastoma in the retina 3.hepatoblastoma in the live4.medulloblastoma in the cerebellum5.neuroblastoma in the adrenal medulla6.embryonal rhabdomyosarcoma in soft tissue
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 Nephroblastoma "Wilms' tumour"
Definition:
Wilms' tumor is a rare kidney cancer that primarily affects children. Also known asnephroblastoma, it's the most common malignant tumor of the kidneys in children.The peak time of Wilms' tumor occurrence is around ages 3 to 4, and it occurs onlyrarely after age 6.Although Wilms' tumor can occur in both kidneys, it tends to affect just one kidney.Wilms' tumor is believed to develop from immature kidney cells.Improved imaging techniques help doctors to determine the extent of the cancer inWilms' tumor and to plan treatment. The outlook for most children with Wilms' tumor is very good.
Gross picture:
synchronous or metachronous bilateral involvement in 5–10%
Usually:
o
Solitary ,well circumscribed ,rounded ,soft consistency
Size variable (median 550 g)
Cut section:
o
 predominantly solid and pale gray or tan gray
o
often cystic change, necrosis, and hemorrhage 
Microscopic picture:
Three major components:
1.
Blastematous areas:
o
extremely cellular& small round-to-oval primitive cells
o
cytoplasm usually scanty& sometimes oncocytoid appearance
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