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Type I Hypersensitivity Responses of the Immune

Type I Hypersensitivity Responses of the Immune

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Published by: wasmj on Jan 06, 2010
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Type I hypersensitivity responses of the immune system are accompanied byeosinophilia. An appropriate, useful type I response would most likely be directedagainst which of the following?A Amyloid proteinB SpirochetesC NeoplasmsD Inhaled dustsE Liver flukes
E) CORRECT. Parasitic infestations can be accompanied by a type I hypersensitivity reaction-
Twelve hours after going on a hike through dense foliage, a 40-year-old man notices aslightly raised and tender irregular reddish rash on one forearm that was not covered byclothing. This rash gradually increases in intensity for 2 days and then fades away after two weeks. Which of the following forms of immunologic hypersensitivity is most likelydemonstrated in this patient?A Type I hypersensitivityB Type II hypersensitivityC Type III hypersensitivityD Type IV hypersensitivity
This is a contact dermatitis, typical of exposure to a plant such as poison ivy.
The second pregnancy for a 23-year-old woman appears uncomplicated until ultrasoundperformed at 19 weeks shows hydrops fetalis. The fetal organ development isconsistent for 19 weeks, and no congenital anomalies are noted. Her first pregnancywas uncomplicated and resulted in the birth of a normal girl at term. The currentpregnancy ends with birth of a baby boy at 32 weeks gestation. On examination thebaby has marked icterus. Laboratory studies show a hemoglobin of 7.5 g/dL, andneonatal exchange transfusion is performed. Which of the following immunologicmechanisms best explains this infant's findings?
A Anti-receptor antibodyB Loss of self toleranceC Immune complex formationD Delayed type hypersensitivityE Complement mediated cell destruction
(E) CORRECT. This is immune hydrops, probably from Rh incompatibility, resulting in maternal antibodycrossing the placenta and destroying baby's RBCs through complement mediated lysis, a form of type IIhypersensitivity reaction.-
A 60-year-old woman has developed crippling arthritis over the past 20 years. Onphysical examination the arthritis primarily involves her hands and feet, with marked joint deformities characterized by ulnar deviation and swan-neck deformities of her fingers. She has an irregular heart rate. Laboratory studies show that her rheumatoidfactor titer is markedly elevated, but her antinuclear antibody test is negative. A rectalbiopsy shows submucosal deposition of pink amorphous material that stains positivelywith Congo red. Which of the following precursor proteins most likely gave rise to thesedeposits?A Serum amyloid-associated proteinB Lambda immunoglobulin light chainsC TransthyretinD Amyloid precursor proteinE Beta-2-microglobulin
A)CORRECT. She has rheumatoid arthritis, which is a chronic inflammatory condition that can becomplicated by amyloidosis of the reactive systemic variety with SAA protein contributing toamyloid deposition in a variety of organs.
B)A 9-year-old boy has a sore throat. A throat culture grows group A hemolyticstreptococcus. He receives antibiotic therapy. However, 17 days later hedevelops dark-coloured urine. Laboratory studies show 3+ blood on urinalysis. Arenal biopsy is performed. On immunofluorescence staining the biopsy showsgranular deposition of IgG and complement around glomerular capillary loops.
Which of the following immune hypersensitivity mechanisms is most likelyresponsible for this pattern of findings?
A Type I
B Type II
C Type III
D Type IV
-(C) CORRECT. The child has a poststreptococcal glomerulonephritis typical of immune complexdeposition, a form of type III hypersensitivity
-A 27-year-old woman is given intravenous penicillin to treat infectiveendocarditis. Within minutes of starting this therapy, she begins to have severedifficulty breathing with respiratory stridor and tachypnea. She suddenly developsan erythematous skin rash over most of her body. Her symptoms are most likelyto be produced by release of which of the following chemical mediators?-A Interleukin 1-B Bradykinin-C Complement C5a-D Histamine-E Thromboxane
-(D) CORRECT. She is having a type 1 hypersensitivity reaction with systemic anaphylaxis, in partmediated by histamine released from mast cells, which causes vascular permeability. About 20%of all persons will have some reaction to penicillin or similar drugs, and a few of these will be sevQuestions in inflammation
Question 1A 22-year-old man develops marked right lower quadrant abdominal pain over the pastday. On physical examination there is rebound tenderness on palpation over the rightlower quadrant. Laparoscopic surgery is performed, and the appendix is swollen,erythematous, and partly covered by a yellowish exudate. It is removed, and amicroscopic section shows infiltration with numerous neutrophils. The pain experiencedby this patient is predominantly the result of the formation of which of the following twochemical mediators?A Complement C3b and IgGB Interleukin-1 and tumor necrosis factor C Histamine and serotonin

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