Prior Adverse Pregnancy Outcome and the Risk of Stillbirth
Authors analyzed a population-based cohort, from 1967 to 2005 from the Medical Birth Registry of Norway, to estimate whether a history of fetal growth restriction, abruptio placentae, preeclampsia, orlive preterm birth is associated with excess risk of stillbirth in subsequent pregnancy. Analysis revealed,after preterm births with gestational age 22–27, 28–32, and 33–36 weeks, odd of stillbirth were 5.7(95% CI 4.2–7.6), 2.6 (95% CI 2.1–3.3), and 1.7 (95% CI 1.5–1.9), respectively. Odds ratios of stillbirthsubsequent to pregnancies with SGA, preeclampsia, and abruptio placentae were 1.7 (95% CI 1.6–1.9),1.6 (95% CI 1.5–1.9), and 2.8 (95% CI 2.2–3.5), respectively, and increased with severity of theconditions. Gestational age below 33 weeks with preeclampsia or SGA carried 6–9 and 6–13 fold effectson later stillbirth, respectively. Men who fathered a pregnancy with preterm preeclampsia weresignificantly more likely to father a stillbirth in another woman (OR 2.4, 95% CI 1.1–5.5).
Svein R et al. Obstetrics & Gynecology 2009; 114:1259-70.
Decreased Regional Brain Volume and Cognitive Impairment in Preterm Children at Low Risk
Volumetric MRI evaluation of 20 preterm children who were
determined to be at low risk forneurodevelopmental deficits
and were born between 30 and 34 weeks’ gestational age
without majorneonatal morbidity or cerebral pathology in the
neonatal period and 22 matched, term subjects revealeddecreased regional cortical grey-matter (GM) and white-matter (WM) in
preterm children. Pretermchildren showed global and regional GM volume
reductions in several brain areas, including temporal andparietal
lobes and concomitant WM volume reductions in the same areas,
although only the left temporalregions achieved statistical
significance. Global intellectual performance in the preterm
group wassignificantly decreased compared with control subjects.
Neither behavioral nor emotional problems werefound in the
et al. Pediatrics. 2009;124: e1161-e1170.
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