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Quiz Hematology Oncology Part2

Quiz Hematology Oncology Part2

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Published by iman
oncology
oncology

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Published by: iman on Jan 08, 2010
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01/16/2013

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Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 1 -
Hematology/Oncology #1 – Immunology: Cancer
1) Which of the following cases occurring during B cell development would be lethal for the lymphocyte?a) Translocation of an oncogene resulting in permanent activation of the oncogene b) Translocation of an oncogene with an immunoglobulin gene promoter c) Chromosomal breaks during class switching and somatic hypermutationd) Joining of chromosomal segments from different chromosomese) Repair of chromosomal breaks during immune-receptor gene recombination2.1) What is the role of the oncogene c-myc, which is commonly translocated to theimmunoglobulin heavy chain on chromosome 8?a) Stimulates cell apoptosis b) Stimulates lymphocyte proliferationc) Permanently prevents cell divisiond) Protects against cell apoptosise) Destroys cancer cells2.2) What is the role of the oncogene Bcl-2, which is commonly translocated tochromosomes 14 and 18?a) Stimulates cell apoptosis b) Stimulates lymphocyte proliferationc) Permanently prevents cell divisiond) Protects against cell apoptosise) Destroys cancer cells3.1) Which of the following viruses is associated with Kaposi sarcoma, which isspecifically seen in immunocompromised patients (e.g. AIDS)?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)3.2) Which of the following is a retrovirus that encodes Tax protein, leading to a raremalignancy?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)3.3) Burkitt lymphoma is a consequence of polyclonal activation of B cells by bothmalaria and which of the following?a) Human Herpes Virus 3 (VZV) b) Human Herpes Virus 4 (EBV)c) Human Herpes Virus 5 (CMV)d) Human Herpes Virus 8 (HHV-8)e) Human T lymphocyte virus 1 (HTLV1)4.1) Monoclonal gammopathy of undetermined significance (MGUS) are due tomonoclonal immunoglobulins produced in response to some infections. They may also be present in what healthy population?
 
Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 2 -a) Infants b) Childrenc) Hospital workersd) Adultse) Elderly4.2) How is lymphoma usually diagnosed?a) Morphology in blood or bone marrow b) Presence of T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.3) How is chronic lymphocytic leukemia (CLL) distinguished?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.4) How is acute lymphocytic leukemia (ALL) usually diagnosed?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry4.5) How is lymphoid malignancy diagnosed?a) Morphology in blood or bone marrow b) Presence T cell receptor genesc) Abnormal monoclonal cellsd) Lymph node biopsye) Flow cytometry5) What type of tumor antigen is involved in tyrosinase-secreting melanocytes?a) Developmental proteins b) Lineage-specific proteinsc) Viral proteinsd) Proteins produced through translocationse) None of the above6) Which of the following tend to be the most immunogenic as they are not present in anormal individual?a) Developmental proteins b) Lineage-specific proteinsc) Viral proteinsd) Proteins produced through translocationse) None of the above7) What immune cells are required to eradicate solid tumors?a) Neutrophils b) Lymphocyte B cellsc) Lymphocyte T cells
 
Hematology & Oncology Part 2 14Mar2009DO NOT DISTRIBUTE - 3 -d) Lymphocyte NK cellse) Macrophages8) Tumors are able to evade the adaptive immune system by losing the ability to presentantigen to T cells or by decreasing the expression of major histocompatibility complex(MHC). Cells expressing low levels of MHC may be targeted for destruction by whattype of immune cell, acting as a backup system?a) Neutrophils b) Lymphocyte B cellsc) Lymphocyte T cellsd) Lymphocyte NK cellse) Macrophages9) Infusions of anti-CD20 monoclonal antibodies (passive immunotherapy) can reduce or cure up to 50% of which of the following?a) B cell lymphoma b) T cell lymphomac) NK cell lymphomad) Lymphomatoid papulosise) Sézary disease10) An infusion of which of the following would activate T cells directly (activeimmunotherapy), but has side effects including capillary leak syndrome?a) Cytokine IL-2 b) Cytokine interferons (IFN)c) Cytokine IL-10d) Cytokines IL-1 and IL-18e) Lymphokine-activated killer (LAK) cells
Hematology/Oncology #2 – Pathology
1.1) What is the most common type of non-Hodgkin lymphoma in the United States,which have a characteristic t(14;18) and cells that are awry or with effacement?a) Acute lymphoblastic leukemia (ALL) b) Chronic lymphocytic leukemia (CLL)c) Small lymphocytic leukemia (SLL)d) Follicular lymphomae) Diffuse large B-cell lymphoma1.2) What is the type of the most common primary tumor arising in bone of adults?a) Burkitt lymphoma b) Mantle cell lymphoma (MCL)c) Marginal zone lymphoma (MALToma)d) Plasma cell neoplasms (e.g. multiple myeloma)e) Lymphoplasmacytic lymphoma (Waldenström macroglobulinemia)2) Which of the following type for Hodgkin Disease is the most common?a) Nodular sclerosis b) Mixed cellularityc) Lymphocyte-richd) Lymphocyte-depletione) Lymphocyte predominance (NLPHL)

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