P1.02The E. coli Integrated Network and the Self Contained Regulatory Loops
H Ma, I Goryanin,
University of Edinburgh,
We reconstructed an integrated network of E. coli which includes different types of cellular interactions. Based on it, we introduced the concept of self contained loopand studied the dynamic behaviour of such loops.
P1.03Data Integration to Constrain Computational Modelling in Synthetic Biology
J S Hallinan, M Pocock, A Wipat,
This paper describes describes ongoing work using data integration andevolutionary computation for designing and modelling genetic circuits. The aim is toproduce designs which are biologically plausible enough to be useful in syntheticbiology.
P1.04Self-Assembly of Protein Amyloid
C F Lee,
This work studies the thermodynamical properties of protein amyloid self-assemblyand the mechanical properties of amyloid fibrils.
P1.05An RNAi-Enhanced Logic Circuit: Cancer-Specific Detection and Destruction
A Swaminathan, J Monk, P Cowgill, R Weiss, P Purnick, P Guye,
We developed an RNAi based logic circuit that detects cancer by evaluating internalcell state through mRNA expression patterns. The circuit controls translation of apro-apoptotic factor, allowing targeted destruction specific to cancer cells.
P1.06 YeSOil A Yeast Sensor for Real Extra Virgin Olive Oil
R Bergamasco, M Graziano, M A Ricci, G Russo, L Marucci, M di Bernardo,
University of Naples Federico II
I Cantone, G Cuccato, V Siciliano, M PCosma, D di Bernardo,
TIGEM Telethon Institute of Genetics and Medicine,
The goal of our project is to transform Saccharomices cerevisie in a BiologicalSensor able to distinguish between Extra Virgin Olive Oil and not Edible Olive Oilconstructing a synthetic network.
P1.07Computational Design of Synthetic Molecular Clocks with Targeted CellGrowth
G Rodrigo, J Carrera,
Instituto de Biologia Molecular y Celular de Plantas, CSIC-UPV,
B Canton, D Endy,
We have designed synthetic molecular clocks following a computational evolution of circuits. In addition, we analyse the in vivo response of the chassis when hostingour synthetic constructs in plasmids
P1.08Biological Implementation of Algorithms
A Becerra, F Castro, L Martinez, Y Robles, F Ramirez, P Padilla, E Samra,
University of Mexico (UNAM),
Mexican Institute of Technology