 Pathophysiology

o A. schematic diagram (book based)

Non-modifiable factors: Modifiable factors:

• Poor envi’t sanitation (presence of
• AGE and SEX – both are affected since
dengue is a universal infection stagnant water container junk tires
and bottle)
• SEASON – Aedes aegypti is more • Poor practice to protect self against
commonly found in tropical and
mosquitoes
subtropical countries
• Other lifestyle practices

Mosquito bite (AEDES AEGYPTI)

Dengue virus enters the body Interruption in the normal

homeostatic environment of the body
carried by circulation and multiplies

Immune response by the body (defense

Fever mechanism of the body to foreign bodies)
The body responds by
producing physiologic
changes aimed at elevating Body induces the Immune adherence to
body temperature. action of the cytokines platelets produced
and prostaglandins
Platelet injury/damage
Joint pain Joint Cytokine and
inflammation prostaglandin release

B
A

A
 A

Increase capillary or vascular

permeability and fragility
B
Ruptured capillaries

Extravasations of fluid Oral mucosa Nasal mucosa Bone marrow Thrombocytopenia

Petechiae
Gum Maturation
bleeding Epistaxis arrest of Bleeding
Decrease tissue
megakaryocytes
perfusion GIT

Liver damage
GIT bleeding Gastric
erosion and stasis Low WBC
Altered liver function
ulceration
Coagulation defect
Vomiting

Melena

DEATH Shock Hypotension Decrease blood

volume

Narrowed
PP Low BP
Decrease Hct
and Hbg
 Pathophysiology (Client Centered)

Modifiable factor:
Non-modifiable factors: • ENVIRONMENT – the patient spent
• AGE and SEX – both are affected a day swimming in a public pool
since dengue is a universal infection which was surrounded by plants

Mosquito bite (AEDES AEGYPTI)

Dengue virus enters the body Interruption in the normal

carried by circulation and multiplies homeostatic environment of the
body

Immune response by the body (defense

mechanism of the body to foreign bodies)

Fever with weakness The body responds by

Dec. 12 and 13 producing physiologic
changes aimed at elevating
body temperature.
Body induces the Immune adherence to
action of the cytokines platelets produced
and prostaglandins
Platelet injury/damage
Cytokine and
prostaglandin release

B
A
 A

Increase capillary or vascular

permeability and fragility
B
Ruptured capillaries

Extravasations of fluid Extremities Nasal mucosa Bone marrow Thrombocytopenia

(lower) Hemorrhage
Maturation
Decrease tissue Dec.12
Epistaxis arrest of
perfusion GIT Dec.12 megakaryocytes
Petechial rashes
Dec. 12
Abdominal
pain
Dec. 12 Low WBC
(6.7) Dec.12

Decrease blood
volume

Decreased Hct and Hgb

Hct (0.24) Dec.14 and 15
Hgb (81) Dec.14