Inhalational agents

Are Anesthetic drugs that taken up byinhalational through the lungsMACIs the minimum alveolar concentration of anesthetic at 1 atmosphere that producesimmobility in 50% of those patients exposedto a noxious stimulus

)Nitrous oxide )N2O

Non-irritating, sweet smelling and colorlessgasClinical uses:3.Obstetric analgesia4.Relief of pain in acute trauma5.Burns & painful dressings6.Dental anesthesia7.Analgesia during surgery

Adverse effects

•Impurities with higher oxides of nitrogen spc.Nitrogen dioxide )NO2 which lead tolaryngospasm, cyanosis , met hemoglobin &pulmonary odema•Hypotension if given with benzodiazepines or opioids•Aplastic anemia )after 6-24 h due toinactivation of vit B12 & defect in folatemetabolism